脑转移癌放疗联合替莫唑胺化疗的疗效观察  

Radiotherapy combined with temozolomide chemotherapy in the treatment of cerebral metastatic carcinoma

作　　者：孙一[1] 董勇[1] 肖鹏[1] 方佳彦 

机构地区：[1]广东东莞市石龙人民医院肿瘤中心,东莞523320

出　　处：《中国实用神经疾病杂志》2014年第7期77-78,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨脑转移癌采用放疗联合替莫唑胺化疗的治疗效果。方法回顾性分析2011-10—2013-07我院脑转移癌患者76例的临床资料,按照1∶1原则随机将患者分为治疗组与对照组各38例,治疗组进行放疗联合替莫唑胺化疗,对照组单纯放疗,比较2组患者的治疗效果。结果治疗组症状改善32例,改善率84.2%,对照组症状改善20例,改善率52.6%;治疗组生活质量提高30例(78.9%),稳定6例(15.7%),下降2例(5.4%);对照组分别为18例(47.3%)、12例(31.6%)和8例(21.1%)。2组比较差异均有统计学意义(均P<0.05)。结论脑转移癌采取放疗联合替莫唑胺化疗的效果显著,且患者生活质量改善明显优于单纯放疗。Objective To investigate the efficacy of radiotherapy combined with temozolomide chemotherapy in the treat-ment of cerebral metastatic carcinoma.Methods Seventy-six patients with cerebral metastatic carcinoma treated in our hospital from October 2012 to July 2013 were selected ,and were randomly divided them into treatment group and control group ,38 ca-ses in each group. Treatment group was given combined radiotherapy and temozolomide chemotherapy ,control group received radiotherapy alone. The efficacy of two groups after treatment was analyzed.Results After treatment ,the symptoms had im-proved in 32 patients of treatment group ,the improvement rate was 84.2% ,which were 20 cases and 52.6% in control group.In the treatment group ,the improved ,stable and deceased quality of life after treatment were 30 cases（78.9% ） ,6 cases （15.7% ） and 2 cases（5.4% ） ,respectively ,which were 18 cases（47.3% ） ,12 cases（31.6% ）and 8 cases（21.1% ）in control group ,respectively.There were significant differences between the two groups （all P＜0.05）.Conclusion The efficacy and im-provement of life quality of combined radiotherapy and temozolomide chemotherapy for cerebral metastatic carcinoma are signifi-cantly better than the single chemotherapy.

关 键 词：脑转移癌 放疗 替莫唑胺 

分 类 号：R739.41[医药卫生—肿瘤]