TNF-α、IL-6在炎症性肠病发病机制中的研究进展  

Research Progress of Tumor Necrosis Factor Alpha and Interleukin-6 in the Pathogenesis of Inflammatory Bowel Disease

作　　者：唐齐林[1] 周国华[2] 王为 

机构地区：[1]南华大学附属南华医院消化内科,湖南衡阳421002 [2]解放军第一六九医院消化内科,湖南衡阳421002

出　　处：《医学综述》2014年第7期1174-1176,共3页Medical Recapitulate

摘　　要：炎症性肠病是一类病因不明的胃肠道慢性非特异性炎症,其发病过程是包括多种细胞因子在内的自身免疫的异常,最终导致组织的损伤,属于自身免疫性疾病的一种,其中肠道免疫系统调节异常在其发病机制中起着极其重要的作用,而作为重要的促炎因子和免疫调节因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)在炎症性肠病的发病过程中参与炎症的发生以及信号的转导。该文就近年来TNF-α、IL-6在炎症性肠病发病机制中的研究予以综述。Inflammatory bowel disease is a kind of unknown etiology of chronic nonspeeific inflammation of the gastrointestinal tract, the onset process of which includes a variety of cytokines immune abnormalities, eventually leading to the tissue damage;it is a kind of autoimmune disease,and the intestinal immune system dysregulation plays an extremely important role in the pathogenesis; tumor necrosis factor alpha and interleu- kin-6, as proinflammatory factors and immune adjustment factors are involved in inflammation and signal transduction in the pathogenesis of inflammatory bowel disease. Here is to make a review of the tumor necrosis factor alpha and interleukin-6 role in the pathogenesis of inflammatory bowel diseases.

关 键 词：肿瘤坏死因子Α 白细胞介素6 炎性肠病 

分 类 号：R574.53[医药卫生—消化系统]