奥卡西平混悬液治疗学龄前儿童癫痫疗效及安全性研究  

Oxcarbazepine oral suspension in partial epilepsy of preschool-aged children： an efficacy and safety study

作　　者：陈健[1] 邹丽萍[1] 赵锰[1] 鞠俊[1] 

机构地区：[1]解放军总医院儿童医学中心,北京100853

出　　处：《中华神经医学杂志》2014年第4期398-401,共4页Chinese Journal of Neuromedicine

摘　　要：目的观察奥卡西平混悬液治疗学龄前儿童部分性癫痫的疗效、耐受性和安全性。方法选择解放军总医院儿童医学中心自2009年8月至2012年8月诊治的48例学龄前部分性癫痫患儿，应用奥卡西平混悬液治疗，起始剂量10mg／（kg·d），维持剂量30-40mg／（kg·d）。以治疗前3个月癫痫发作的频率为对照，对治疗后3个月、6个月内的疗效、不良反应、耐受性及安全性进行自身对照观察。疗效判定标准：癫痫发作减少100％为完全控制：减少75％～99％为显效：减少50％-74％为好转；减少〈50％为无效。结果治疗3、6个月后完全控制率分别为41．7％、50％，总有效率（完全控制＋显效＋好转）分别是79．2％、79．2％。治疗6个月内，3例因皮疹退出（6．3％）；发生不良反应12例（25％），不良反应为皮疹、睡眠增多、纳差、视物模糊；多数不良反应持续时间短且症状轻微。结论奥卡西平混悬液治疗学龄前儿童部分性癫痫安全可靠，不良反应小，依从性好。Objective To evaluate the efficacy, tolerability and safety of oxcarbazepine oral suspension in partial epilepsy of preschool-aged children. Methods Forty-eight preschool-aged children with partial epilepsy, admitted to out hospital from August 2009 to August 2012, were chosen in our study; they were treated with oxcarbazepine oral suspension with an initial dose of 10 mg/（kg？d）, and a maintenance dose of 30-40 mg/（kg, d）. The efficacy, adverse reactions, tolerability and safety 3 and 6 months after treatment were investigated, and compared with the controls （the fi＇equency of epileptic seizures of these children 3 months before treatment）. The treatment outcomes were evaluated by seizure frequency as completely seizure free （100% seizure reduction）, markedly effective （75%-99% seizure reduction）, effective （50%-74% seizure reduction） and invalid （〈50% seizure reduction）. Results The completely seizure free rates for 3 and 6 months after treatment were 41.7% and 50%, and the total effective rates （completely seizure free＋ markedly effective＋ effective） were 79.2% and 79.2%. Three patients gave up treatment because of rash. Adverse reactions occurred in 12 patients （25%）, including rash, increased sleep, anorexia and blurred vision, which were transient and mild. Conclusion Treatment of oxcarbazepine oral suspension is safe and reliable on epilepsy with mild adverse reactions and good compliance in preschool-age children.

关 键 词：癫痫 奥卡西平 口服混悬液 学龄前儿童 自身对照 

分 类 号：R742.1[医药卫生—神经病学与精神病学]