颅内动脉瘤破裂风险因素分析  

Risk factors of ruptured intracranial aneurysms： a clinical study

作　　者：康慧斌[1] 彭汤明[1] 钱增辉[1] 纪文军[1] 吴京[1] 吴中学[1] 刘爱华[1] 

机构地区：[1]北京市神经外科研究所、首都医科大学附属北京天坛医院神经外科,北京100050

出　　处：《中华神经医学杂志》2014年第4期402-404,共3页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（30901557）;北京市高层次卫生人才（2011-3-036）;北京天坛医院“栋梁工程”未来学科骨干（DLB2011-09）;北京市自然科学基金（7142032）

摘　　要：目的探讨瘤体直径、血压、瘤颈宽度、患者性别、年龄、吸烟、饮酒与颅内动脉瘤破裂风险的相关性。方法回顾性分析首都医科大学附属北京天坛医院神经外科自2011年1月至2012年12月收治的928例颅内动脉瘤患者的临床资料，按动脉瘤是否破裂分为破裂组（411例）和未破裂组（517例），多因素Logistic回归分析影响颅内动脉瘤破裂的风险因素。结果2组患者的性别、高血压和吸烟者比例、瘤体直径、瘤颈宽度比较差异均有统计学意义（P〈0．05）；Logistic回归分析显示瘤体直径是颅内动脉瘤破裂的独立危险因素（P=0．001）。结论颅内动脉瘤破裂风险与动脉瘤瘤体直径相关，与血压、瘤颈宽度、患者性别、年龄、吸烟、饮酒无关。Objective To investigate the correlation of rupture risk of intracranial aneurysms with aneurysm diameter, blood pressure, neck width, gender, age, and smoking and alcohol histories of the patients. Methods Retrospective analysis of the clinical and radiological data of 928 patients with intracranial aneurysm, admitted to our hospital from January 2011 to December 2012, was performed; according to rupture situation, these patients were divide into mptured group （n=411） and unruptured group （n=517）; univariate analysis and multivaviable Logistic regression analysis were used to analyze the rupture risk of intracranial aneurysms, including aneurysm diameter, blood pressure, neck width, gender, age, and smoking and alcohol histories. Results Univariate analysis showed that there were statistical significances between the two groups on aneurysm diameter, blood pressure, aneurysm neck width, gender, smoking history （P〈0.05）; multivariate Logistic regression analysis showed that aneurysm diameter was the independent risk factor of rupture ofaneurysms （P=-0.001）. Conclusion Aneurysm diameter is a key risk of rupture for intracranial aneurysms, while rupture of intracranial aneurysms is not correlated to the blood pressure, aneurysm neck width, gender, age, and smoking and alcohol histories.

关 键 词：颅内动脉瘤 破裂 直径 高血压 宽度 

分 类 号：R739.41[医药卫生—肿瘤]