MiRNA-146a rs2910164基因多态性与大肠癌易感性的系统评价  

Association between miRNA-146a rs2910164 gene polymorphism and susceptibility to colorectal cancer: A systematic review

作　　者：谢文群[1] 谭诗云[1] 王晓凡[1] 

机构地区：[1]武汉大学人民医院消化内科,湖北省武汉市430060

出　　处：《世界华人消化杂志》2014年第6期890-897,共8页World Chinese Journal of Digestology

摘　　要：目的:评价miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性的相关性.方法:全面检索Pubmed、Excerpta Medica Database(Embase)、Chinese Biomedical Literature Database(CBM)and the Cochrane L i b r a r y、维普、万方数据库,收集研究miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性相关性的文献.对miRNA-146a rs2910164 G/C各基因型的比较模型(G vs C、GG vs CC、GG vs GC、GC vs CC、GG+GC vs CC、GG vs GC+CC)进行定量综合分析.结果:共纳入7篇文献,共有大肠癌患者2978例,健康对照3576例.Meta分析尚未发现miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性具有相关性(G vs C:OR=0.82,95%CI:0.52-1.30,P=0.41;GG vs CC:OR=1.10,95%CI:0.72-1.40,P=0.97;GG vs GC:OR=1.10,95%CI:0.81-1.28,P=0.91;GC vs CC:OR=0.99,95%CI:0.70-1.41,P=0.96;GG+GC vs CC:OR=1.00,95%CI:0.72-1.39,P=0.99;GG vs GC+CC:OR=1.00,95%CI:0.81-1.24,P=0.98).结论:本研究尚未发现miRNA-146a rs2910164G/C基因多态性与大肠癌易感性之间具有相关性.AIM： To accurately evaluate the association be- tween the miRNA-146a rs2910164G/C polymor- phism and susceptibility to colorectal cancer. METHODS： An electronic search of PubMed, Excerpta Medica Database （Embase）, Chinese Biomedical Literature Database （CBM）, the Co- chrane Library, Weipu and Wanfang Database was performed to collect all the publications investigating the association between miR- 146a rs2910164G/C polymorphism and risk of colorectal cancer. We then analyzed the differ- ences in miRNA-146a rs2910164G/C genotypes （G vs C, GG vs CC, GG vs GC, GC vs CC, GG ＋ GC vs CC, GG vs GC ＋ CC） between cases andcontrols by meta-analysis RESULTS： Seven studies involving 2978 cases and 3576 controls were found to be eligible for meta-analysis. We summarized the data on the association between miR-146a rs2910164G/C polymorphism and risk of colorectal cancer in the overall population. In the overall analysis, there was no evidence for an association be- tween the miR-146a rs2910164 polymorphism and the risk of colorectal cancer （G vs C： OR = 0.82, 95%CI： 0.52-1.30, P= 0.41; GG vs CC： OR = 1.10, 95%CI： 0.72-1.40, P = 0.97; GG vs GC： OR = 1.10, 95%CI： 0.81-1.28, P = 0.91; GC vs CC： OR = 0.99, 95%CI： 0,70-1.41, P = 0.96; GG ＋ GC vs CC： OR = 1.00, 95%CI： 0.72-1.39, P = 0.99; GG vs GC ＋ CC： OR = 1.00, 95%CI： 0.81-1.24, P =0.98）. CONCLUSION： This meta-analysis demonstrat- ed that the miR-146a rs2910164 polymorphism is not associated with colorectal cancer susceptibil- ity.

关 键 词：MIRNA 基因多态性 大肠癌 META分析 

分 类 号：R735.34[医药卫生—肿瘤]