致瘤性DNA病毒的整合机制及致瘤效应  

The Mechanism and Tumorigenesis of Oncogenic DNA Virus Integration

作　　者：喻正源[1,2] 宋亚莉[2] 龚朝建[2] 曾朝阳[1,2,3] 卢建红[2] 李小玲[1,2,3] 熊炜[1,2,3] 李桂源[1,2,3] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院,湖南省肿瘤医院,长沙410013 [2]中南大学肿瘤研究所,卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室,长沙410078 [3]中南大学湘雅三医院疾病基因组研究中心,湖南省非可控性炎症与肿瘤重点实验室,长沙410013

出　　处：《生物化学与生物物理进展》2014年第4期324-331,共8页Progress In Biochemistry and Biophysics

基　　金：国家高新技术研究发展计划(863)(2012AA02A206);国家“111”计划(111-2-12);国家自然科学基金(81171930,81171931,81172189,81272254,81272298,181372907,91229122);湖南省自然科学基金(14JJ1010)资助项目~~

摘　　要：恶性肿瘤是一种严重危害人类生命和健康的疾病,而致瘤性DNA病毒是多种恶性肿瘤的主要致病因子.致瘤性DNA病毒的整合可以使宿主细胞正常组织逐步向炎症组织转变,并可导致癌变.病毒整合可引起宿主细胞基因组不稳定和重排,产生新的融合基因,并导致宿主基因表达异常,也是病毒本身得以复制,逃避宿主免疫识别并长期维系自我生存的机制之一.本文综述了目前对致瘤性DNA病毒整合规律以及致瘤性DNA病毒整合致瘤效应的研究和进展,并展望致瘤性DNA病毒整合的研究方向以及在肿瘤发生、发展、诊断和治疗上的应用前景.Cancer is one kind of diseases which seriously jeopardized the health of human beings. Oncogenic DNA virus is a leading factor for many kinds of cancer. Virus DNA integration could cause host cell organization inflammation and tumorigenesis. Its integration could induce the host genome instability and rearrangement. It could also cause the alterations of host transcriptome such as viral promoter driven human transcription, viral-human transcription fusion and form new fusion gene, and the host gene expression change. Meanwhile, it＇s one of the mechanisms for virus replication, escape the host immunological recognition and maintain itself. The review focus on the research and the progress of the oncogenic DNA virus integration regulation and the carcinogenic effect of its integration. We also prospect the oncogenic DNA virus integration research direction and the application on the cancer occurrence, development, diagnose and therapy.

关 键 词：致瘤性DNA病毒 整合 肿瘤 基因组 新一代测序技术 

分 类 号：Q25[生物学—细胞生物学] R730[医药卫生—肿瘤]