人血浆脂蛋白相关磷脂酶A2与缺血性脑血管病的关系  

The association between lipoprotein-associated phospholipase A2 and ischemic cerebrovascular disease

作　　者：陈仁玉[1,2] 王惠娟[1,2] 于慧丹[1,2] 吴倩[1,2] 王晓艳[1,2] 李文菊[1,2] 

机构地区：[1]河北医科大学第二医院神经内科 [2]河北省神经病学重点实验室,石家庄050000

出　　处：《脑与神经疾病杂志》2014年第2期109-113,共5页Journal of Brain and Nervous Diseases

基　　金：河北省科技支撑计划项目(112061177D)

摘　　要：目的探讨Lp-PLA2与缺血性脑血管病的关系,为预测缺血性脑血管病的发生提供准确简便快捷的方法。方法选择缺血性脑血管病患者98例为病例组和30例健康者为对照组,病例组包括短暂性脑缺血发作组21例,无症状脑梗死组31例,症状性脑梗死组46例。病例组与对照组均采用双抗体酶联免疫吸附测定法(ELISA)检测血浆Lp-PLA2水平,同时检测血浆CHOL、TG、LDL-C、HDL-C水平。结果①病例组患者血浆Lp-PLA2水平明显高于对照组(P<0.01);②有症状脑梗死组患者血浆LP-PLA2水平高于短暂脑缺血发作组和无症状脑梗死组(P<0.01),三组比较差异有统计学意义;③无症状脑梗死组患者血浆Lp-PLA2水平高于短暂性脑缺血发作组(P<0.01)。结论 Lp-PLA2可能与缺血性脑血管病的严重程度有关,Lp-PLA2可以作为预测缺血性脑血管病风险的一个生物学标志物。Objective To investigate the relationship between the Lp-PLA2 and ischemic cerebrovascular to predict the occurrence of ischemic cerebrovascular disease with accurate simple and quick method .Methods Selectly 98 cases of cerebral infarction in patients as the case group and 30 cases of healthy subjects as control group , 98 cases of the case group include TIA group 21 cases, asymptomatic cerebral infarction group 31 cases, symptomatic cerebral infarction group 46 cases.The case group and control group were to detect the plasma Lp-PLA2 level by double antibody enzyme linked immunosorbent assay （ ELISA ） , while detecting the plasma CHOL , TG, LDL-C, HDL-C level.Results ①The Lp-PLA2 levels of in the case group were significantly higher than the control group and had statistically significant （ P〈0.01 ） .②The Lp-PLA2 levels of symptomatic cerebral infarction group were significantly higher than both TIA group and asymptomatic cerebral infarction group .The differences among three group had statistically significant（P〈0.01）.③The Lp-PLA2 levels of the asymptomatic cerebral infarction group were higher than the TIA group .The differences between two group had statistically significant （ P〈0.01 ） .Conclusion Plasma Lp-PLA2 may be associated with the severity of ischemic cerebrovascular disease and we speculate that the Lp-PLA2 possibly becomes to a biological indicators ,which predicts risk of the ischemic cerebrovascular diseases .

关 键 词：缺血性脑血管疾病 脂蛋白相关磷脂酶A2 生物学标志物 

分 类 号：R743.32[医药卫生—神经病学与精神病学]