基于“体质可调”理论治疗非酒精性脂肪性肝炎临床研究  

Clinical Study on Treating Non-alcoholic SteatohepatitisBased on the Theory of“Constitution Being Adjustable”

作　　者：郑昕[1] 王亚平[1] 张志银[1] 庄敏之[1] 朱艳[1] 郭兆玮[1] 张迪[1] 周菲[1] 韩静[1] 吴瑛[1] 

机构地区：[1]上海交通大学附属第一人民医院分院中医脂肪肝病专科,上海200081

出　　处：《世界中医药》2014年第3期308-310,共3页World Chinese Medicine

基　　金：上海市中医肝病重点学科(编号:ZYXK2012009);上海市虹口区医学重点课题(编号:虹卫1002-02);上海市虹口区卫生局青年业务骨干临床导师制培养项目

摘　　要：目的:通过纠正体质偏向的方法自拟处方观察非酒精性脂肪性肝炎的临床疗效。方法:筛选出的80例痰瘀体质非酒精性脂肪性肝炎患者分成治疗组40例和对照组40例。两组患者均接受基础治疗(包括合理饮食和适当运动)。治疗组使用益肝解毒方进行药物干预治疗,对照组使用益肝灵治疗,治疗周期为3个月。疗程结束后观察非酒精性脂肪性肝炎患者痰瘀体质积分、肝功能、血脂的变化情况。结果:治疗组治疗后在痰瘀体质积分的改善上与对照组比较具有统计学意义(P<0.05);治疗组治疗后血清ALT、AST、GGT均值与对照组比较具有统计学意义(P<0.05)。治疗组综合有效率为75.00%,对照组综合有效率为52.25%,两组比较有统计学意义(P<0.01)。结论:益肝解毒方能有效改善NASH患者的体质偏向,可降低NASH患者肝酶指标,具有改善NASH患者血脂和体重指数的趋势。Objective： To observe the therapeutic effect of TCM on NASH based on the theory of constitution being adjustable. Methods ： Eighty patients with nonalcoholic steatohepatitis of phlegm-blood stasis constitution were screened and divided into control group （ n = 40） and treatment group（ n = 40 ）. Patients in both groups were treated with suitable diet and exercise called as foundation therapy. Treatment group gave patients TCM of Yiganjiedu formula. Control group applied silymarin （SM）. The courses of treatment of both groups were 3 months. The changes of constitution scores, hepatic function and blood fat were observed to evaluate. Drugs that potential- ly affect liver function and serum lipid were not allowed to use during the observation period. Results：The results of constitution scores between control group and treatment group had statistically significant differences （ P 〈 0. 05 ）. The comparisons of hepatic function be- tween the two groups had statistically significant differences （ P 〈 0. 05 ）. The total effective rate of treatment group was 75.00% , and that of the control group was 52.25%. The results had statistical significance （ P 〈0.01 ）. Conclusion：The treatment of TCM can sig- nificantly regulate constitution scores and reduce levels of ALT, AST, GGT, and it has the trend of lowering body mass index （BMI） and blood lipid.

关 键 词：体质 非酒精性脂肪性肝炎 临床研究 

分 类 号：R229[医药卫生—中医基础理论]