食管癌术后肺动脉栓塞的预测研究  

The prediction research of pulmonary embolism after surgery of esophageal carcinoma

作　　者：张润起[1] 王鹏[1] 

机构地区：[1]泰山医学院附属泰山医院,山东泰安271000

出　　处：《泰山医学院学报》2014年第2期93-95,共3页Journal of Taishan Medical College

摘　　要：目的探讨食管癌手术后肺动脉栓塞(以下简称肺栓塞)患者的血浆纤维蛋白原、D-二聚体变化规律以及手术前后有无下肢深静脉血栓与肺栓塞的关联。方法所有食管癌患者术前、术后第1、3、5天分别化验D-二聚体水平及血浆纤维蛋白原,将发生肺栓塞的患者检测结果与同期未发生栓塞者进行比较,同时观察肺栓塞与手术前、后下肢深静脉血栓是否相关。运用SPSS13.0软件进行统计学分析。结果肺栓塞患者术后第1、3、5天血浆D-二聚体水平及术后第1天血浆纤维蛋白原含量均高于未发生肺栓塞患者,差异有统计学意义(均P<0.01)。手术前是否存在下肢深静脉血栓与术后肺栓塞并无关联(P>0.05),但术后下肢深静脉血栓形成易导致肺栓塞。结论通过监测血浆D-二聚体和纤维蛋白原水平及术后尽早发现新发下肢深静脉血栓有助于提高食管癌术后肺栓塞的预警。Objective： Investigated the association between pulmonary embolism in patients with esophageal carcinoma after surgery and plasma D - dimer levels, fibrinogen levels and deep vein thrombosis. Methods ： Plasma D - dimers and fi- brinogens of 1,3,5 days after surgery were observed. Those with pulmonary embolism comparied with normmal people. As- sociation was observed between pulmonary embolism and deep vein thrombosis before surgery and after surgery. Statistical a- nalysis was performed by using SPSS13.0 software. Results ： Plasma D - dimer levels of 1,3,5 days after surgery and post- operative day 1 plasma tibrinogen levels with pulmonary embolism in patients were respectively higher than those in patients without pulmonary embolism, the difference was statistieally significant（ P 〈0.05 ）. There are no association between post- operative pulmonary embolism, and deep vein thrombosis existing before surgery, the difference was not statistically signifi- eant（P 〉0.05 ）. But the venous thrombosis after surgery easily lead to pulmonary embolism. Conclusions： It can help to improve postoperative pulmonary embolism warning by monitoring plasma D - dimer and fibrinogen levels, early detection of new - onset deep vein thrombosis after surgery of esophageal carcinoma.

关 键 词：食管癌 纤维蛋白原 D-二聚体 肺动脉栓塞 

分 类 号：R735.1[医药卫生—肿瘤]