酶解淀粉样前体蛋白的β分泌酶研究进展  

New development of β-secretase

作　　者：桑华春[1] 任宏伟[2] 王文清[1] 茹炳根[2] 

机构地区：[1]北京大学技术物理系,北京100871 [2]北京大学生命科学院蛋白质工程及植物基因工程国家重点实验室,北京100871

出　　处：《生命科学》2001年第1期1-5,共5页Chinese Bulletin of Life Sciences

摘　　要：β淀粉样蛋白（β－Ａｍｙｌｏｉｄ，Ａβ）是阿尔茨海默症（Ａｌｚｈｅｉｍｅｒ＇ｓｄｉｓｅａｓｅ，ＡＤ）病人脑中老年斑（ｓｅｎｉｌｅ ｐｌａｇｕｅｓ， ＳＰ）的主要成分。 β分泌酶（β－ｓｅｃｒｅｔａｓｅ）是水解淀粉样前体蛋白（ａｍｙｌｏｉｄ ｐｒｏｔｅｉｎｐｒｅｃｕｒｓｏｒ，ＡＰＰ）产生β淀粉样蛋白所必须的。多年来众多科学家一直在寻找β分泌酶。最近三个研究组通过不同的研究途径各自独立发现了具有β分泌酶活性的酶，该酶很可能就是寻觅已久的β分泌酶。β分泌酶的发现不仅为药物设计提供了依据，而且为β淀粉样蛋白的生物学研究提供了线索。Alzheimer's disease is characterized by the progressive formation in the brain of senile plagues , which are mainly made up of β-amyloid. β-secretase is needed to free β-amyloid from its precursor protein, known as APP. Many researchers have been trying to find β-secretase for year after year. Recently three research teams found enzymes with β-secretase activity. It is most likely that they are the longsought β-secretase. 'Finding the β-secretase enzyme is a very important development, not only for drug developman but also for the clues it will give us about [amyloid] biology.

关 键 词：Β分泌酶 Β淀粉样蛋白 阿尔茨海默症 老年性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]