养正消积胶囊对肝癌经动脉化疗栓塞后生活质量的影响  

The effect of Yangzhengxiaoji capsule on life quality after transcatheter arterial chemoembolization of HCC

作　　者：冯景见[1] 檀军丽[1] 郭燕[1] 王贵法[1] 赵敬霞[1] 吴小良[1] 王晓燕[1] 高彤[1] 

机构地区：[1]石家庄市第一医院肿瘤科,050011

出　　处：《疑难病杂志》2014年第4期349-353,共5页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察养正消积胶囊对肝癌经动脉化疗栓塞(TACE)后生活质量的影响。方法将原发性肝癌患者60例随机分为对照组和治疗组,其中对照组30例,只接受TACE;治疗组30例,给予TACE+养正消积胶囊;疗程均为28 d。于术前、术后采用QOL核心量表(QLQ-C30)评估,评估其中5个功能领域、3个主要症状领域和6个单项条目。结果治疗组剔除2例,对照组剔除3例,治疗组临床获益(CB)为89.3%(25/28),对照组临床获益(CB)为92.6%(25/27),差异无统计学意义(P>0.05)。2组患者功能量表评分差异无统计学意义(P>0.05)。治疗组在疲乏、恶心呕吐、疼痛、睡眠障碍、食欲减退、腹泻等评分与治疗前比较有明显改善(P<0.05,P<0.01)。对照组仅疲乏、食欲减退较治疗前改善(P<0.05)。对照组疲乏、恶心呕吐、疼痛、睡眠障碍、食欲减退、腹泻评分分别降低了7.83%、4.01%、2.78%、7.41%、7.41%、2.74%,治疗组分别降低了11.91%、5.07%、13.99%、15.47%、15.47%、9.53%,治疗组的改善较对照组更为明显(P<0.05)。TACE术后出现骨髓抑制,对照组WBC降低多于治疗组(P<0.05),ALT、AST 2组比较差异亦有统计学意义(P<0.05)。结论养正消积胶囊能显著提高肝癌患者TACE后的生活质量。Objective To observe the effect of Yangzhengxiaoji capsule on quality of life in hepatocellular carcinoma （HCC） after transcatheter arterial chemoembolization （TACE）.Methods 60 patients with primary liver cancer were random-ly divided into control group and the treatment group with 30 patients in each group , control group only accept TACE .In treat-ment group, patients received TACE ＋Yangzhengxiaoji capsule;treatment lasted 28 d.Preoperative and postoperative QOL using the core scale （ QLQ-C30） assesses five functional areas , three main symptoms areas and six individual entries .Rseults Two cases were removed in treatment group and control group excluded three cases ,treatment groups＆#39;clinic benefit （ CB） rate was 89.3%（25/28）, the control group＆#39;s CB rate was 92.6%（25/27）, the difference was not statistically significant （ P 〉0.05）.2 groups of patients function scores showed no significant difference （ P 〉0.05）.In the treatment group, fatigue, nausea, vomiting, pain, sleep disorders, loss of appetite, diarrhea score significantly improved compared with before treat-ment （ P 〈0.05, P 〈0.01）.In control group, only fatigue, loss of appetite were improvement than before treatment （ P 〈0.05）.Control group＆#39;s fatigue, nausea, vomiting,pain,sleep disorders, loss of appetite, diarrhea scores were decreased 7.83%,4.01 %2,.78%,7.41%,7.41%,2.74%,the treatment group decreased by 11.91%,5.07%, 13.99%,15.47%, 15.47%,9.53%,improvement in the treatment group was more significantly than the control group （ P 〈0.05）.TACE post-operative bone marrow suppression , WBC lower than the control group treated group （ P 〈0.05）, ALT, AST 2 group differ-ence was also statistically significant （ P 〈0.05）.Conclusion Yangzhengxiaoji capsule can significantly improve quality of life in hepatocellular carcinoma after transcatheter arterial chemoembolization .

关 键 词：养正消积胶囊 肝癌 原发性 经动脉化疗栓塞 生活质量 

分 类 号：R735.7[医药卫生—肿瘤]