上海妇女妊娠期激素水平与乳腺癌发病率模式的生态学研究  

Ecologic study on the relationship between pregnant hormone levels and breast cancer incidence pattern in Shanghai female population

作　　者：徐飚[1] 俞顺章[1] 李旭亮[1] 汤明荣 宋月华 胡晓敏[4] 法金生[5] 

机构地区：[1]上海医科大学公共卫生学院流行病学教研室,上海200032 [2]上海南汇县周浦医院 [3]上海国际和平妇婴保健院 [4]上海医科大学附属妇产科医院 [5]上海市第二人民医院

出　　处：《肿瘤》2001年第1期32-35,共4页Tumor

摘　　要：目的　乳腺癌发病率在不同国家间有明显差异 ,而同一国家或地区内则发病率相近。此研究旨在探讨乳腺癌的发病率模式与女性胎儿乳腺组织发育过程中宫内激素环境的关系。方法　采用生态学研究方法 ,在前期对发病率迥异的美国和上海妇女妊娠期激素水平比较的基础上 ,进一步比较上海市区和南汇县孕妇在第 16和 2 7孕周与妊娠有关的各种激素水平。结果　上海市区和南汇县孕妇 16和 2 7周前后雌二醇、雌三醇、孕酮等妊娠期激素差别无显著意义 (P>0 .0 5 )。结论　相对其类似的乳腺癌发病率模式 。Objective There is an obvious geographical variation in breast cancer incidence among various countries, but within country the variation is usually small. It is unknown whether this variation is related to the difference of pregnant hormone levels that form the intrauterine hormonal millen for the offspring. Methods On the basis of comparing the pregnant hormone levels between USA and Chinese women, further analysis of this ecological study was taken to compare the pregnancy hormone levels between women from urban and rural areas of Shanghai. Results The difference of pregnancy hormone levels at 16 and of 27 weeks of gestation for these two groups of women had no statistical significance Conclusion The results are reasonable to explain the similarity of breast cancer incidences in Shanghai urban and rural women.

关 键 词：妊娠中期 激素类 乳腺肿瘤 发病率 

分 类 号：R737.901[医药卫生—肿瘤]