肠外营养配合肝动脉栓塞化疗对肝癌的影响  

INFLUENCE OF PARTIAL PARENTERAL NUTRITION WITH FAT EMULSION ON LIVER FUNCTION AND TUMOR GROWTH IN PATIENTS WITH LIVER CANCERS

作　　者：施先艳[1] 高志清[1] 肖建群[1] 朱龙庆 

机构地区：[1]湖北医科大学第二医院消化内科,武汉430071

出　　处：《肿瘤》2001年第1期39-41,共3页Tumor

摘　　要：目的　探讨糖一脂双能源部分肠外营养 (PPN)配合肝动脉栓塞化疗 (TACE)对肝癌患者肝功能、营养状态及肿瘤生长的影响。方法　 5 8例肝癌患者随机分为含脂组 (30例 )与对照组 (2 8例 ) ;两组行 TACE每月 1次 ,连续 3次 ,同时 ,按组别每月给予含或不含脂肪乳剂 PPN 1周、连续 3个月 ;治疗前及治疗后每月测 AL T、AST、TB、血清蛋白、AFR与 AFU,治疗后每月计算肿瘤生长率。结果　与对照组比较 ,治疗后含脂组 AL T、AST及 TB有不同程度下降 ,血清蛋白有不同程度升高 ;两组治疗后 AFP与 AFU变化幅度及每月肿瘤生长率相近。结论　糖一脂双能源 PPN可改善肝癌患者肝功能及营养状态 ;配合 TACE治疗 。Objective To evaluate the effect of partial parenteral nutrition (PPN) with fat emulsion and transarterial chemoembolization (TACE) on liver function, serum proteins and tumor growth in patients with liver cancers. Methods 58 patients with liver cancers were divided into 2 groups at random: Group 1,30 cases treated with fat emulsion PPN for 1 week once a month combining with TACE for 3 months, Group 2,28 cases no such treatment were given as control. Their liver function, serum proteins and tumor markers were examined before and once a month after PPN. And tumor growth rates were measured respectively once a month after PPN. Results After PPN with TACE, serum ALT at second and month, AST at first and month, TB at third month were lower in Group 1 than in Group 2 ( P <0 05); PA at the first to third month, Fn at the third month, Tf at the second and third month were higher in group 1 than in Group 2 ( P <0 05); AFP and AFu and tumor growth rates per month were similar in both groups. Conclusion Administration of PPN with fat emulsion for patients with liver cancers may improve their liver function and nutritional status but has no effect on cancer growth rate.

关 键 词：肝肿瘤 脂肪乳剂 静脉注射用 胃肠外营养 治疗 

分 类 号：R735.705[医药卫生—肿瘤]