D6S2420与1型糖尿病和LADA的相关性研究  

Association studies of D6S2420 with IDDM and LADA in Chinese Han population

作　　者：阿周存[1] 张思仲[2] 肖翠英[2] 李卫东[3] 

机构地区：[1]大理医学院生物教研室 [2]华西医科大学附属第一医院医学遗传研究室,邮政编码610041 [3]华西医科大学附属第一医院内分泌科,邮政编码610041

出　　处：《中国糖尿病杂志》2001年第1期11-13,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金!资助 (3999342 0 )

摘　　要：目的　了解 1型糖尿病 (IDDM)的易感位点 IDDM5与中国人群 IDDM和成人迟发型 IDDM(L ADA)的关系。方法　应用 PCR- PAGE结合产物直接测序的技术 ,在 10 5例无亲缘关系的成都地区正常汉族人 ,48例 1型糖尿病患者以及 2 2例成人迟发型 1型糖尿病 L ADA患者中 ,对 1型糖尿病易感位点 IDDM5的连锁标记 D6 S2 42 0的多态性进行分析。结果　 D6 S2 42 0位点的等位基因 A4的频率在 1型糖尿病组中显著高于正常对照组 ,为 2 6 .0 4% vs12 .86 %、P<0 .0 385 ;在 L ADA组中 ,各等位基因的频率分布与正常对照组相比无显著性差异 ,P值均 >0 .0 5。结论　 1型糖尿病的易感位点 IDDM5与中国人群的 1型糖尿病相关 ,但与 L ADA不相关 ;1型糖尿病与 L ADA发病的遗传因素可能存在差异。Objective The polymorphism of D6S2420 locus,a genetic marker linked closely to type 1 diabetes mellitus 5 (IDDM5) was studied by polymerase chain reaction polyacrylamide gel.Methods Electrophoresis (PCR PAGE) and direct sequencing of PCR products were conducted in 105 normal Chinese Hans,48 patients with type 1 diabetes mellitus (IDDM) and 22 patients with latent autoimmune diabetes in adults (LADA).Results The frequency of allele A 4 at D6S2420 locus was increased significantly in patients with IDDM compared with that in the control group (26.04% vs 12.86%, P <0 05).No differences in allele frequencies at D6S2420 locus was observed between patients with LADA and control group ( P >0 05).Conclusion IDDM5 is associated with IDDM,but not with LADA in Chinese population,there may be difference in genetic factors involved between IDDM and LADA.

关 键 词：Ⅰ型糖尿病 成人迟发性自身免疫性糖尿病 相关性 

分 类 号：R587.1[医药卫生—内分泌]