补骨合剂促进口腔种植体骨整合的组织形态计量学研究  

THE HISTOMORPHOMETRY STUDY OF THE EFFECT OF “BUGU” CAPSULE ON THE OSSEOINTEGRATION OF DENTAL IMPLANTS

作　　者：李楠[1] 王和鸣[1] 潘在兴 叶起清 谢丹榕 

机构地区：[1]福建中医学院,福州350003 [2]福建省直机关医院

出　　处：《中医正骨》2001年第2期3-5,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：福建省科委资助

摘　　要：为证实补骨合剂对口腔种植体骨整合的促进作用 ,运用组织形态计量学方法对杂种犬口腔种植体模型进行了实验研究 ,并设立空白对照组对比。结果显示 ,实验组第 1周成骨细胞指数、第 2周骨矿化沉积速率显著高于对照组 (P <0 .0 1) ;第 4、12周实验组骨融合指数比对照组显著提高 ;第 4周实验组骨缺损面积显著减少 (P <0 .0 5 )。提示补骨合剂可以提高种植区早期骨矿化沉积速率 ,增加种植区早期成骨细胞数目 ,促进骨基质合成 ,提高种植区骨性结合率 ,缩短骨整合时间。To investigate the mechanism of the effect of “BuGu” Capsule(BGC) on osseointegrat ion and provide data for the practical use of BGC, by measuring related index of the influence of BGc on the dental implant osseointegration. A randomized, control experiment was conducted. Ten adult dogs were divided into two groups: experimental group and control group. Three left maxillofacial tooth were pulled ou t of all dogs, and were implanted with two titanium plast three month later. The dogs of experimental group were ingestd with BGC. The implanted maxillofacial part were sampled to observe the changes of implant bone interface immediately 1, 2,4,8,12 week after the surgery. The osteoblast index(OBI) after the first week and the mineral apposition rate(MAR) was significantly higher in the experimental group than those of control group, the osseointegration index(OI) increase significantly compared with the control group, and the area of bone defect decr eased significantly in the experimental group. It was concluded that BGC can pro mote the osseointegration of oral maxillofacial implants;the effect of BGC on the osseointegration is achieved by the following mechanism:to promote the synthes is of bone matrix; to increase the MAR and deposition of calcium and phosphorus on the collager surface.

关 键 词：骨内种植体 骨整全 补骨合剂 骨组织超微结构 口腔种植体 

分 类 号：R783.1[医药卫生—口腔医学]