肿瘤干细胞与血管生成拟态的研究进展  

Research progress on cancer stem cells and vasculogenic mimicry

作　　者：李艳[1] 谷彦军[2] 郭小荣[1] 

机构地区：[1]天津市人民医院妇产科,天津300121 [2]武警后勤学院附属医院病理科,天津300162

出　　处：《武警后勤学院学报（医学版）》2014年第2期168-171,共4页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：血管生成拟态是近年来发现的存在于高度恶性肿瘤的血液供应模式,其形成机制尚未完全阐明。肿瘤干细胞具有成瘤性、多向分化潜能和便于分离纯化的分子标记。目前已在多种实体肿瘤中检测到肿瘤干细胞,如胶质瘤、黑色素瘤、乳腺癌和卵巢癌等。最近研究表明肿瘤干细胞参与了血管生成拟态的形成,尤其是CD133+的肿瘤干细胞。本研究就肿瘤干细胞与血管生成拟态研究进展进行综述。Vasculogenic mimicry （VM） is a new blood supply pattern of high malignant tumor whose formation has not been fully elucidated. Cancer stem cells （CSCs） are characterized by tumorigenicity, potential muhilineage differentiation and molecular marker that allows for their reliable identification and purification. CSCs have been identified in many solid tumors, such as glioma, melanoma, breast cancer and ovarian cancer. Recent study shows that CSCs are involved in the formation of VM, especially CD 133 positive CSCs. This paper reviews the research progress on cancer stem cells and vasculogenie mimicry.

关 键 词：肿瘤干细胞 血管生成拟态 进展 

分 类 号：R730.2[医药卫生—肿瘤]