非典型抗精神病药对精神分裂症患者激越行为的随机对照研究  

Clinical Efficacy of Atypical Antipsychotic Drug in Patients with Mental Division with Agitated Behavior

作　　者：王琦[1] 周丹[1] 李萍[1] 谢红涛[1] 

机构地区：[1]上海市普陀区精神卫生中心,中国200065

出　　处：《中国健康心理学杂志》2014年第3期325-327,共3页China Journal of Health Psychology

摘　　要：目的对比阿立哌唑、喹硫平、奥氮平的3种给药方案对精神分裂症患者激越行为的临床疗效。方法将符合精神分裂症诊断标准的117例入院伴有兴奋冲动行为的精神分裂症患者,随机分为阿立哌唑合并喹硫平组(A组)、阿立哌唑合并奥氮平组(B组)和喹硫平合并奥氮平组(C组);治疗后,对3组患者进行PANSS评分测定,并对不良反应发生情况进行分析。结果对3组患者治疗前后PANSS评分对比研究显示,治疗1天后,组间两两相比,A组与C组差异有显著性(t=2.645,P<0.05),B组与C组差异有显著性(t=2.044,P<0.05);治疗1周后组间两两相比,A组与B组差异有显著性(t=2.650,P<0.05),B组与C组差异有显著性(t=2.156,P<0.05);在治疗3天及1周后3组疗效具有显著性差异(χ2=4.197,3.987;P<0.05)。不良反应分析表明,3组患者在肌强直、震颤、扭转型运动以及难以静坐等不良反应发生率差异具有统计学意义(χ2=39.028,15.613,4.037;P<0.05);其中A组肌强直、震颤以及难以静坐等不良反应发生率显著高于B组(χ2=41.446,15.613,12.664;P<0.05),C组肌强直、震颤及扭转型运动等不良反应发生率明显高于B组(P<0.05)。结论阿立哌唑联合喹硫平及喹硫平联合奥氮平治疗精神分裂症患者激越症状疗效显著,可作为精神分裂症兴奋激越治疗方案之一。Objective To explore the clinical efficacy of aripiprazole combined with quetiapine, olanzapine in agitated behavior of pa- tients with schizophrenia. Methods A total of 117 patients associated with impulsive behavior who met the diagnostic criteria of CCMD -3 for schizophrenia were randomly divided into three groups. Group A was treated with aripiprazole combined with quetiapine, B with aripiprazole and olanzapine and C with quetiapine and olanzapine. After treatment, PANSS scores were measured in three patients, and the incidence of adverse reactions were analyzed. Results In 1 days after treatment, there was significant difference in PANSS between A group and C （t = 2. 645, P 〈 0.05 ）, B group and C group （t = 2.044, P 〈 0.05 ） ; In 1 weeks after treatment, there was significant differ- ence in PANSS score between A group and B group（ t = 2.650, P 〈 0.05 ）, B group and C group（ t = 2. 156, P 〈 0.05 ）. In 3 days and af- ter a week, treatment effect of three groups had significant difference （X2 = 4. 197,3. 987 ,P 〈 0.05）. Adverse reaction analysis showed that there were significant differences in myotonia, tremor, torsional motion and the difficulty of sit-ins among three groups （ X2 = 39. 028, 15. 613,4.037,P 〈 O. 05 ）;The adverse reaction rate of myotonia, tremor and difficult to sit in A group were significantly higher than those in B group （ X2 = 41. 446,15.613,12.664 ; P 〈 0.05 ）, adverse reaction rate of myotonia, tremor and twisting motion in C group were significantly higher than those in B group （P 〈 0.05 ）. Conclusion The clinical efficacy of Aripiprazole combined with quetiapine and quetiapine combined with olanzapine are significant in the treatment of agitated behavior of patients with schizophrenia, which can be used as one of the clinical treatment scheme of schizophrenia with excitement and agitation.

关 键 词：精神分裂症 阿立哌唑 喹硫平 奥氮平 激越行为 

分 类 号：B845.4[哲学宗教—心理学] R749.3[医药卫生—神经病学与精神病学]