具类辣素结构丙烯酰胺的合成及其抑菌和防污性能  

Synthesis,Bacteriostasic Activity and Antifouling Capability of Acrylamides Containing Capsaicin Moieties

作　　者：于晓琳[1] 于良民[1] 姜晓辉[1] 

机构地区：[1]中国海洋大学海洋化学理论与工程技术教育部重点实验室,青岛266100

出　　处：《应用化学》2014年第5期594-599,共6页Chinese Journal of Applied Chemistry

基　　金：国家高技术研究发展计划(863计划)(2010AA09Z203;2010AA065104);国家科技支撑计划(2012BAB15B02);泰山学者攀登计划资助~~

摘　　要：以N-羟甲基丙烯酰胺和苯酚类化合物为原料,合成了N-(2-羟基-3-丙烯酰胺甲基-4,6-二甲基苄基)丙烯酰胺(HMABA)、N-(2-羟基-3-丙烯酰胺甲基-4,5-二甲基苄基)丙烯酰胺(AMHBA)、N-(3,5-二甲基-4-羟基苄基)丙烯酰胺(MHBA)、N-(3,6-二甲基-4-丙烯酰胺甲基-2-羟基苄基)丙烯酰胺(MAHBA)和N-(2-甲氧基-4-甲基-5-丙烯酰胺甲基苄基)丙烯酰胺(MMABA)5个类辣素结构的丙烯酰胺衍生物。通过红外光谱(IR)、核磁波谱(1H NMR)、质谱(HR-MS)和元素分析对化合物的结构进行了表征。抑菌试验表明,HMABA对金黄色葡萄球菌和大肠杆菌的抑制效果最好,最低抑菌浓度均可达0.125 g/L。将此5个化合物作为防污剂制备海洋防污涂料,120 d的实海结果表明,基本无污损海生物附着。Five acrylamide compounds containing capsaicin moieties were synthesized. Their structures were confirmed by IR spectroscopy, 1H NMR spectroscopy, HRMS and elemental analysis. The results of bacterium- inhibition experiments concluded that the minimal inhibitory concentration （MIC） of five tag compounds respectively to Staphyloccocus aureus and Escherichia coli both were 0. 125 g/L. The antifouling properties of coatings were examined by immersing test panels in the sea for more than 120 days. The result shows that the test panels are covered with a few macroscopic fouling organisms balanus.

关 键 词：含类辣素结构的丙烯酰胺 合成 抑菌 防污性能 

分 类 号：O625[理学—有机化学]