石墨烯-纳米金复合物修饰电极用于异烟肼及抗坏血酸的同时测定  

Simultaneous Voltammetric Determination of Isoniazid and Ascorbic Acid Based on Graphene / Gold Nanocomposites Modified Electrode

作　　者：杨君[1] 刘志敏[1] 展海军[1] 王珍玲[1] 

机构地区：[1]河南工业大学化学化工学院,河南郑州450001

出　　处：《分析测试学报》2014年第4期403-408,共6页Journal of Instrumental Analysis

基　　金：国家自然科学基金项目(21275039);河南省教育厅高校青年骨干教师基金项目(001135)

摘　　要：制备了石墨烯-纳米金（GR/Au）复合物修饰的玻碳电极,并将其用于异烟肼（INZ）和抗坏血酸（AA）的同时检测.在0.1 mol×183;L-1 PBS（pH3.5）缓冲溶液中,采用循环伏安法分别考察了INZ及AA的电化学行为.结果显示,INZ及AA的氧化峰电流均与扫速（50～300 mV×183;s-1）的平方根呈良好线性关系,且复合物修饰电极对INZ及AA的氧化显示出高的催化性能,二者之间产生明显的峰分离（△V=170 mY）.在最优实验条件下,当AA存在时,INZ的氧化峰电流与其浓度在3.0×215;10-6～1.5 ×215;10-4 mol×183; L-1范围内呈良好的线性关系,其检出限为8.0×215;10-7 mol×183;L-1.而当INZ存在时,AA的氧化峰电流与其浓度在3.0×215;10-5～1.0×215;10-3 mol×183;L-1范围内呈良好的线性关系,其检出限为6.0×215;10-6 mol×183; L-1.将此修饰电极用于药物中INZ及AA的测定,结果满意.A glassy carbon electrode modified with GR/Au nanocomposites was prepared for the sim- ultaneous determination of isoniazid（INZ） and ascorbic acid（AA）. In 0. 1 mol · L-1 PBS（pH 3.5） buffer solution, the electrochemical behaviors of INZ and AA were investigated by cyclic vohametrmy （CV）. The results indicated that the anodic peak currents of both INZ and AA showed linear rela- tionships with the square root of scan rate over a wide range of 50 - 300 mV · s - 1 Furthermore, the nanocomposites modified electrode showed an efficient catalytic role in the electro-oxidation of INZ and AA, leading to a remarkable peak resolution（ AV = 170 mV） between the two compounds. Under the optimal experimental conditions, the anodic peak currents were linear over ranges of 3.0 × 10 -6 _ 1.5 × 10-4 mol ·L-1 for INZ and 3.0 x 10-5 - 1.0 x 10 -3 mol · L-1 for AA, with detection limits of 8.0 × 10 -7 mol · L-1 and 6.0 x 10-s mol · L-1, respectively. The proposed method was successful- ly applied in the determination of INZ and AA in commercial drugs.

关 键 词：石墨烯-纳米金复合物 异烟肼 抗坏血酸 循环伏安法 

分 类 号：O657.1[理学—分析化学] R977.4[理学—化学]