血管内皮生长因子及其受体在胃癌研究中的进展  

Research on the advances in the studies of VEGF and its receptors in gastric cancer

作　　者：杨力 侯建章[2] 侯振江[2] 

机构地区：[1]沧州市运河区南陈屯乡卫生院,河北沧州061001 [2]沧州医学高等专科学校,河北沧州061001

出　　处：《中国医学装备》2014年第4期68-70,共3页China Medical Equipment

摘　　要：肿瘤生长和转移的基础是新血管的生成,而新血管的生成主要取决于血管生长因子及其抑制因子的调控,其中研究最多、最重要的是血管内皮生长因子(VEGF)及其受体。VEGF是目前发现最重要的促进肿瘤血管形成的因子,可增加血管通透性、促进血管内皮细胞增殖,参与肿瘤生长和淋巴管转移。人体多种实体瘤均有VEGF及其受体的过高表达,其在肿瘤组织和血清中的显著表达促进肿瘤血管的形成,并与预后密切相关。Neovascularization is the basis of tumor growth and metastasis. Angiogenesis depends mainly on the regulation of vascular endothelial growth factor and angiogenesis inhibiting factor. The vascular endothelial growth factor and its receptor are the most important and are studied most. The expression of them increased significantly in gastric cancer tissue and serum.. They promote angiogenesis of tumor. They are closely related to the prognosis of patient. The vascular endothelial growth factor and its receptor in the gastric cancer are reviewed in this article.

关 键 词：血管内皮生长因子 胃癌 组织 血清 

分 类 号：R735.2[医药卫生—肿瘤]