大肠癌ICAM-1的表达及临床意义  

Expression of ICAM-1 in Colorectal Carcinoma and Its Clinical Significance

作　　者：杨明智[1] 王培戈[2] 陈积圣[1] 伍衡[1] 张敬智[2] 李玉军[3] 

机构地区：[1]中山医科大学孙逸仙纪念医院外科,广东广州510120 [2]青岛医学院附属医院外科,山东青岛266003 [3]青岛医学院附属医院病理科,山东青岛266003

出　　处：《癌症》2001年第3期311-313,共3页Chinese Journal of Cancer

摘　　要：目的：检测大肠癌 ICAM-1的表达探讨其与临床病理因素的关系。方法：应用免疫组织化学方法（ SABC法），采用 ICAM-1单克隆抗体测定 55例病理证实的大肠癌标本及 8例大肠腺瘤标本中 ICAM-1的表达。结果：大肠癌 ICAM-1阳性 41例，表达率 75％高于大肠腺瘤，差异显著（ P< 0.05） ;发生淋巴结转移的大肠癌 ICAM-1表达率高于未发生转移的大肠癌，差异显著（ P< 0.05），比较未发生转移的大肠癌与大肠腺瘤 ICAM-1的表达则无显著性差异。结论：大肠癌 ICAM-1的过度表达与淋巴结转移密切相关。Objective： This study was designed to determine the expression of ICAM-1 in colorectal cancer and its clinical significance. Methods： The expression of ICAM-1 in 55 samples of colorectal carcinoma and 8 samples of adenomas were invested using immunohistochemical staining. Results： There were 41 positive cases in 55 colorectal cancer samples. The positive rate of ICAM-1 in colorectal cancer was significantly higher than that of adenomas（ P< 0.05） , ICAM-1 in colorectal cancer was significantly correlated with lymph node metastasis. However， there was no significantly difference in ICAM-1 expression between adenomas and colorectal cancer without lymph node metastasis. Conclusion： Over-expression of ICAM-1 was significantly related to lymph node metastasis.

关 键 词：细胞间粘附分子-1 大肠肿瘤 免疫组织化学 ICAM-1 

分 类 号：R735.3[医药卫生—肿瘤]