射频消融与再手术切除治疗直径≤5cm复发性肝细胞癌的临床疗效  

Clinical efficacy of radiofrequency ablation and repeated surgical resection for treatment of recurrent hepatocellular carcinoma( diameter ≤ 5 cm)

作　　者：李志强[1] 孙海[1] 邓小明[1] 张丰深[1] 

机构地区：[1]解放军第324医院,重庆400020

出　　处：《临床军医杂志》2014年第4期385-387,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨射频消融(RFA)与再手术切除对瘤体直径≤5 cm的复发性肝细胞癌的临床疗效。方法按照随机数字表法将112例患者分为RFA组和再手术切除组,比较两组治疗效果。结果两组患者肿瘤组织均完全清除;RFA组ALP峰值和胆红素峰值均低于再手术切除组,两组比较,差异具有统计学意义(P<0.05);两组患者生存率比较,差异无统计学意义(P>0.05);RFA组主要并发症为穿刺部位疼痛,再手术切除组并发症较多,两组比较,差异具有统计学意义(P<0.05)。结论 RFA与再手术切除治疗直径≤5 cm的复发性肝细胞癌具有相当的临床使用价值,同时RFA具有并发症少、微创、可重复、操作简单等优点。Objective To investigate the clinical efficacy of radiofrequency ablation （RFA） and repeated surgical resection the treatment of recurrent hepatocellular carcinoma （diameter ≤ 5cm）. Methods According to the random number table 112 patients were divided into RFA group and surgical resection group, and their treatment effects were compared. Results The tumors of the two groups were completely removed. The alanine aminotransferase and bilirubin peak values of the RFA group were lower than that of the surgical resection group （ P 〈 0.05 ）. There was no statistically significant difference in survival rate between the two groups （ P 〉 0.05 ）. The major complication was puncture site pain in the RFA group, while the surgical resection group had more compli- cations than the RFA group （ 16.1% vs 3.6% ） （ P 〈 0.05 ）. Conclusion The clinical efficacies of RFA and repeated surgical resection for recurrent hepatocellular carcinoma equal to or less than 5 em are similar. But RFA has the advantage of few complica- tions, minimal invasion and repeatable and easy operation.

关 键 词：肝肿瘤 复发性肝细胞癌 射频消融 再手术切除 

分 类 号：R735.7[医药卫生—肿瘤]