局部复发性鼻咽癌的临床病理学特征  

Pathological characteristics of loco-regional recurrent nasopharyngeal carcinoma

作　　者：雍娟娟[1,2,3] 吴秋良[1,3] 宗永生[4] 侯景辉[1,3] 梁建中[1,3] 匡亚玲[1,3] 奚少彦[1,3] 卢佳斌[1,3] 

机构地区：[1]中山大学肿瘤防治中心病理科,广州510060 [2]中山大学孙逸仙纪念医院病理科,广州510120 [3]中山大学肿瘤防治中心华南肿瘤学国家重点实验室,广州510060 [4]中山大学中山医学院病理学教研室,广州510080

出　　处：《临床与实验病理学杂志》2014年第4期389-392,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：华南肿瘤学重点实验室鼻咽癌单病种基金资助(303040736005)

摘　　要：目的 探讨局部复发性鼻咽癌的临床病理学特征。方法 收集46例局部复发性鼻咽癌和63例原发性鼻咽癌活检组织,行HE染色、免疫组化、EBERs原位杂交检测。结果 局部复发性鼻咽癌中p63和CK5/6的强阳性表达率均高于原发性鼻咽癌（P=0.005和P=0.026）; Ki-67的强阳性表达率差异无显著性（P=0.387）; 组织坏死、炎性渗出和间质促纤维增生明显; 畸形瘤巨细胞多见,癌细胞鳞状分化程度更高。5例复发性鼻咽癌细胞EBERs原位杂交和LMP-1免疫组化标记均为阴性。结论（1）局部复发性鼻咽癌有2个复发间歇高峰,即2～5年和9～11年。（2）局部复发性鼻咽癌细胞p63和CK5/6强阳性表达率、鳞状分化程度更高,侵袭性更强。（3）10.87%（5/46）的局部复发性鼻咽癌细胞EBERs原位杂交和LMP-1免疫组化标记均为阴性。Purpose To investigate the pathological characteristics of loco-regional recurrent nasopharyngeal carcinoma （rNPC）. Methods Nasopharyngeal biopsy specimens of 46 rNPCs and 63 primary NPCs were collected. HE staining, immunohistochemistry and EBV small RNAs （EBERs） in-situ hybridization were performed. Results The over-expression rates of both p63 and CK5/6 in rNPC were significantly higher than those of primary NPCs （P = 0. 005, P = 0. 026）, while no statistical significance of Ki-67 over-ex- pression existed between the two groups （P = 0. 387）. More necrotic tissues, inflammatory exudates, giant bizarre carcinoma cells, desmoplastic stroma, giant bizarre tumor cells and higher degree of squamons differentiation were found in rNPCs. The carcinoma cells of 5 rNPCs were negative for both EBERs in-situ hybridization and LMP-1 immunohistochemical staining. Conclusion The loco-re- gional rNPC has two peaks of latency interval ： 2 - 5 and 9 - 11 years. The loco-regional rNPC cells have higher degree of squamous differentiation with higher expression of p63 and CK5/6, as well as more invasive ability. In addition, both EBERs in-situ hybridization and LMP-1 immunostaining are negative in 10. 87% （5/46） of loco-regional rNPC.

关 键 词：鼻咽肿瘤 局部复发性鼻咽癌 病理学特征 免疫组织化学 

分 类 号：R739.6[医药卫生—肿瘤]