脑梗死患者血清胱抑素C水平与颅内外动脉硬化性狭窄的相关性  

Study on the relativity of serum cystatin C level and intracranial and extracranial atherosclerosis of cerebral infarction patients

作　　者：汪冰[1,2] 傅佳[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]安徽省第二人民医院神经内科,合肥230022

出　　处：《安徽医科大学学报》2014年第4期512-515,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:090413145)

摘　　要：目的探讨脑梗死患者血清胱抑素C水平与颅内外动脉粥样硬化性狭窄的相关性。方法对119例脑梗死住院患者均行头颅高分辨CT血管造影(CTA)、胱抑素C和高危因素检查。依病变程度分无狭窄组、轻度狭窄组、中度狭窄组和重度狭窄组。将各组中高危因素和胱抑素C水平进行比较,根据胱抑素C水平分血胱抑素C正常组和高胱抑素C组,将两组间动脉狭窄例数进行比较。结果颅内外动脉狭窄组胱抑素C水平显著高于无颅内外动脉狭窄组(P<0.05)。与胱抑素C正常组相比,高胱抑素C组中颅内外动脉狭窄率显著升高(P<0.01)。Logistis多元回归分析显示,胱抑素C、高血压和糖尿病是颅内外动脉粥样硬化性病变的独立危险因素。结论血清胱抑素C水平升高与颅内外动脉粥样硬化性狭窄密切相关,是颅内外动脉粥样硬化性病变的独立危险因素。Objective To evaluate rhe relativity of serum cystatin C level and intracranial and extracranial athero- sclevosis of cerebral infarction patients. Methods A total of 119 cerebral infarction inpatients were examined with cranial CTA, serum cystatin C and high risk factor examination. Based on the lesions level, patients were divided in- to no stenosis group, the mild stenosis group, the moclerate stenosis group and servere stenosis group. The high risk factor and serum cystatin C levels were compared among groups. According to serum eystatin C level, they were di- vided into hypercystatin C and normal cystatin C groups. The number of cranial artery stenosis was compared. Re- suits Intracranial or extracranial artery stenosis group were significantly higher serum cystatin C levels than those without intracranial and extracranial artery stenosis group （P 〈 0.05 ）. Compared with normal serum cystatin C group, hypercystatin C group showed intracranial or extracranial artery stenosis rate significantly increased （P 〈 0. 01 ）. Logistic multivariate regression analysis showed that ： cystatin C, hypeitension and diabetes were independent factors significantly associated with cervicocerebral atherosclerosis. Conclusion The serum level of cystatin C and cervicocerebral atherosclerotic stenosis are closely related, which is independent risk factors for cervicoeerebral ath- erosclersis.

关 键 词：胱抑素C 颅内外动脉硬化 脑梗死 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]