贝那普利对植入VVI患者血浆脑利钠肽及心功能的影响  

The effect of benazepril on cardiac function and brain natriuretic peptid in patients implanted with VVI

作　　者：兰建军[1] 

机构地区：[1]四川省攀枝花市中心医院心内科,617000

出　　处：《临床合理用药杂志》2014年第11期13-14,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 研究贝那普利对植入VVI患者的血浆脑利钠肽水平及左室射血分数的影响.方法 将80例置入VVI起搏器心功能Ⅰ～Ⅱ级（纽约心脏协会分级）的患者随机分为试验组与对照组各40例,对照组予常规基础治疗,试验组在对照组基础上加予贝那普利10mg,1次/d,术前测2组患者血浆脑利钠肽,并行心脏彩色多普勒超声测定2组患者左室射血分数.术后随访3年,重新测定两组患者血浆脑利钠肽和左室射血分数.对2组术前、术后血浆脑利钠肽及左室射血分数状况进行自身及组间对比分析.结果 试验组及对照组术前2组LVEF、BNP比较差异无统计学意义（P＞0.05）,2组患者术后3年LVEF均较术前降低、BNP水平均较术前升高.试验组患者LVEF降低幅度显著小于对照组.试验组患者BNP升高幅度显著高于对照组.差异有统计学意义（P＜0.05）.结论 贝那普利能降低非生理性起搏方式对心脏功能影响.Objective To study and evaluate the efect benazepril on cardiac function and brain natriuretic peptid （BNP） in patients implanted with VVI. Methods 80 cases of patients implanted with VVI whose cardiac function was grade I ~ II according to New York Heart Association （NYHA） were divided into experiment group and control group, each of 40 ca- ses. The control group was received routine therapy, while the experiment group was given benazepril （lOmg 1/d ） for treat- ment. The plasma BNP of 2 groups were measured before operation, and the left ventricular ejection fraction （ LVEF ） of 2 groups were measured by parallel heart color doppler ultrasound. Followed-up for 3 years, the BNP and LVEF of 2 groups were re-measured, which were performed the own and contrastive analysis before and after the operation. Results There were no significant difference of LVEF and BNP between experiment group and control group before operation （ P 〉 0.05 ）. Compared with the preoperative, the LVEF of 2 groups decreased, but the BNP level of 2 groups increased. In experiment group, the LVEF decreased significantly than the control group,while the BNP increased significantly than the control group, the differences were statistically significant （ P 〈 0.05 ）. Conclusion Benazepril can benefit the patients implanted with non - physiologic pacing and reduce the incidence of pacemaker syndrome.

关 键 词：非生理性起搏 脑利钠肽 贝那普利 射血分数 心功能 

分 类 号：R541.7[医药卫生—心血管疾病]