L-FABP与脂类代谢相关疾病的研究进展  

Research progress of liver fatty acid binding protein and lipid metabolic disease

作　　者：孙瑞青[1] 赵严[2,3] 贾蓉蓉[2,3] 邱雷[2,3] 

机构地区：[1]苏州大学附属第一医院消化内科,江苏苏州215006 [2]上海市第十人民医院 [3]同济大学附属第十人民医院消化科

出　　处：《胃肠病学和肝病学杂志》2014年第4期368-372,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金资助项目(81200320);上海市第十人民医院院内基金(12XSGG105)

摘　　要：肝型-脂肪酸结合蛋白(liver-fatty acid binding protein,L-FABP)是一类在肝脏内含量丰富的细胞内蛋白质,它属于细胞内脂质结合家族的一类,并有着特殊的意义,并参与脂肪酸和其他脂质配体的吸收、转运、代谢,与核信号、细胞内脂解作用密切相关,它可以同时结合两个脂肪酸分子,并容纳大量的生理学配体如胆红素、脂肪酸的酰基辅酶等。近年来,有关L-FABP与脂类代谢疾病已成为国内学者关注的热点。本文将就L-FABP的分子结构、功能、基因表达调控及与脂类代谢疾病的研究进展作一综述。Liver fatty acid binding protein（L-FABP） , a cytosolic protein most abundant in liver is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. As a member of the in- tracellular lipid binding protein family, L-FABP can bind two fatty acid molecules simultaneously, accommodate a varie- ty of bulkier physiological ligands such as bilirubin and fatty acyl CoA. In recent years, the L-FABP and lipid metabolic diseases have been discussed hotly. This article aim is to review the structure, conformation, function and its relation- ship of some metabolic diseases.

关 键 词：肝型-脂肪酸结合蛋白 脂肪酸 脂类代谢疾病 

分 类 号：R575.5[医药卫生—消化系统]