Notch信号通路在肝脏发育中的研究进展  

Progress of Notch signaling pathway in liver development

作　　者：程萍[1] 郭传勇[1] 

机构地区：[1]上海市同济大学附属第十人民医院消化科,上海200072

出　　处：《胃肠病学和肝病学杂志》2014年第4期373-375,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81270515;81072005;81172312);上海市科委创新行动计划国际合作课题(11430702400)

摘　　要：Notch是一类高度保守的受体蛋白,广泛存在于各种细胞表面,介导细胞间信号传递。Notch信号通路通过细胞间Notch受体与配体的相互作用,转导细胞信号调控多种细胞增殖、分化、凋亡,从而影响胚胎发育和器官发生发展,是影响细胞命运决定的重要通路之一。近期的研究发现,在哺乳类动物的肝脏发育过程中,Notch信号通路作用尤为巨大,其正常表达对于肝芽的形成、肝祖细胞的分化、胆管细胞和肝细胞的形成、各种肝细胞的增殖和凋亡、肝再生以及发育异常等均有十分重要作用。本文就肝胚胎发育、成熟及肝再生、肝发育异常中Notch信号通路所发挥的作用作一综述。Notch is a highly conserved receptor protein, which is widely present in a variety of cell surface and mediated cell signaling. Interactions of Notch receptor and ligand can transduct cell signal, regulate a variety of cell proliferation, differentiation, apoptosis, thus affect the development of embryonic and organogenesis, which is one of the important pathways that decides the cell fate. Recent studies find that in mammalian liver development process, Notch signa- ling pathway plays an important role in the liver bud formation, differentiation of liver progenitor ceils, the formation of the bile duct and liver cells, cell proliferation and apoptosis, liver regeneration and liver abnormalities developmental. So this article reviewed the role of Notch signaling pathway on the liver embryonic development, liver mature, liver regeneration.

关 键 词：NOTCH信号通路 肝脏发育 

分 类 号：R575[医药卫生—消化系统]