乳腺癌患者血清游离T4水平高于乳腺良性疾病患者  

Patients with breast cancer have a higher level of serum free thyroxine(T4) compared with those with benign breast diseases

作　　者：王亘[1] 陈小松[1] 毛艳[1] 李亚芬[1] 陈伟国[1] 沈坤炜[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院乳腺疾病诊治中心,上海200025

出　　处：《肿瘤》2014年第4期366-369,共4页Tumor

摘　　要：目的：探讨甲状腺激素水平与乳腺癌的发生是否相关。方法：收集2012年8月-2012年11月接受手术治疗的414例乳腺疾病（乳腺良性疾病219例，乳腺癌195例）患者的外周血和基本临床病理资料，检测外周血中总三碘甲状腺原氨酸（total triiodothyronine，TT3）、总甲状腺素（total thyroxine，TT4）、游离T3（free triiodothyronine，FT3）、游离T4（free thyroxine，FT4）和促甲状腺激素（thyroid stimulating hormone，TSH）的水平，比较甲状腺激素水平在乳腺良恶性疾病患者问的差异。结果：年龄、月经状态、生育史、哺乳史、体质指数（body mass index，BMI）、TT4和FT4水平在乳腺良性疾病患者与乳腺癌患者之间的差异有统计学意义（P〈0．01），乳腺癌患者往往年龄较大[比值比（odds ratio，OR）=1．071，95％可信区间（confidence interval，C7）：1．051～1．092，P〈0．0011且FT4水平较高（OR=1．237，95％CI：1．091～1．402，P=0．001）。结论：乳腺癌患者TT4和FT4水平较高，FT4高水平可能与乳腺癌的发生有关。Objective： To explore the relationship between serum thyroid hormone level and the occurrence of breast cancer. Methods： Peripheral blood samples and the clinicopathological characteristics of 414 patients with breast diseases （219 cases of benign breast diseases and 195 cases of breast cancer） undergoing surgery between August 2012 and November 2012 were collected. The levels of serum total triiodothyronine （TT3）, free triiodothyronine （FT3）, total thyroxine （TT4）, free thyroxine （FT4） and the thyroid-stimulating hormone （TSH） were examined to compare the differences in thyroid function tests between the patients with breast benign diseases and cancer. Results： There were statistically significant differences in age, menopausal status, child-bearing history, breast-feeding history, body mass index （BMI）, and serum TT4 and FT4 levels between the patients with breast benign diseases and cancer （P 〈 0.01）. The patients with breast cancer likely had an older age [odds ratio （OR）： 1.071,95% confidence interval （CI）： 1.051-1.092, P 〈 0.001] and a higher serum FT4 level （OR： 1.237, 95% CI： 1.091-1.402, P = 0.001）. Conclusion： The patients with breast cancer seem to have higher levels of serum TT4 and FT4, and the high level of serum FT4 may be related to the occurrence of breast cancer.

关 键 词：乳腺肿瘤 发病率 三碘甲状腺原氨酸 甲状腺素 促甲状腺素 

分 类 号：R737.9[医药卫生—肿瘤]