血浆纤维蛋白原浓度测定在非霍奇金淋巴瘤患者中的临床意义  

Clinical signii cance of plasma i brinogen level in patients with non-Hodgkin's lymphoma

作　　者：王静文[1] 李开春[1] 施展[1] 唐曦[1] 

机构地区：[1]复旦大学附属华东医院肿瘤内科,上海200040

出　　处：《肿瘤》2014年第4期370-373,共4页Tumor

摘　　要：目的:通过血浆纤维蛋白原(i brinogen,FIB)浓度与非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)肿瘤负荷、远处转移及预后的相关性分析,探讨血浆FIB浓度测定在NHL患者中的临床意义。方法:采用Clauss凝固法对124例初治NHL患者作血浆FIB的定量分析。结果:NHL患者的中位血浆FIB浓度明显高于健康人群。当受累淋巴结外器官数量≥2个或受侵淋巴结区域数≥5个或血清乳酸脱氢酶(lactate dehydrogenase,LDH)浓度≥245 U/L时,血浆FIB浓度会发生显著升高。在弥漫性大B细胞淋巴瘤患者中,血浆FIB浓度与预后风险等级呈正相关;当血浆FIB浓度≥5.0 g/L时,其2年无进展生存期有缩短的趋势。结论:当NHL发生多发远处转移时常伴有血浆FIB浓度的升高;高血浆FIB血症可能提示弥漫性大B细胞淋巴瘤患者的不良预后。Objective： To investigate the associations of plasma level of fibrinogen （FIB） with tumor burden, metastasis or prognosis of patients with non-Hodgkin＇s lymphoma （NHL）, and explore the clinical significance of examination of plasma FIB in NHL patients. Methods： The plasma level of FIB in 124 treatment-naive NHL patients was examined and quantified by Clauss clotting method. Results： The plasma level of FIB among NHL patients was significantly higher than that among healthy volunteers. The plasma FIB level was increased considerably in case of the number of involved extranodal sites ≥2, the number of involved lymph node regions ≥5, or the plasma level of lactate dehydrogenase （LDH）≥245 U/L. A positive correlation between the plasma level of FIB and the risk level of prognosis was found among patients with diffuse large B-cell lymphoma （DLBCL）. A tendency of a shortened 2-year progression-free survival （PFS） was seen in patients with DLBCL when the plasma level of FIB was over 5.0 g/L. Conclusion： An increased plasma level of FIB is often seen in NHL patients with multiple distant metastases, indicating a poor prognosis of patients with DLBCL.

关 键 词：淋巴瘤 纤维蛋白原 肿瘤转移 预后 

分 类 号：R733.4[医药卫生—肿瘤]