COX-2与结直肠癌的临床病理参数及5-FU敏感性之间的关系  

Correlation between cyclooxygenase-2 and clinicalpathological characteristics/chemosensitivity to 5-FU in human colorectal cancer

作　　者：章群[1] 胡静[1] 沈洁[1] 刘宝瑞[1] 管文贤[2] 禹立霞[1] 杨觅[1] 任伟[1] 钱晓萍[1] 

机构地区：[1]南京大学医学院附属鼓楼医院肿瘤中心,江苏南京210008 [2]南京大学医学院附属鼓楼医院普外科,江苏南京210008

出　　处：《现代肿瘤医学》2014年第4期869-872,共4页Journal of Modern Oncology

基　　金：国家自然基金(编号:81172094);江苏省自然基金(编号:BK2011095)

摘　　要：目的:研究COX-2与结直肠癌临床病理参数之间的关系及对化疗药作用的影响。方法:共纳入100例经病理确诊的新鲜人结直肠癌标本,5-FU的体外敏感实验通过三维微组织块培养法(HDRA)验证。采用免疫组化法检测对应结直癌组织中COX-2表达水平。结果:COX-2表达水平与肿瘤组织的分化程度呈负相关(P=0.05),与病理分期呈正相关(P=0.02),与神经侵犯呈正相关(P=0.02)。COX-2表达水平与5-FU药物敏感呈负相关(P=0.02)。结论:COX-2与结直肠癌的分期、分型有关,同时与5-FU的耐药相关。Objective：To investigate the expression of COX -2 and its correlation with clinicalpathological charac- teristics and chemosensitivity to 5 - FU in human colorectal cancer. Methods： We collected freshly - removed colorec- tal tumor specimens from 100 patients. Chemosensitivity to 5 - FU was determined by histoculture drug response assay （HDRA）. The correlation between COX -2 expression and clinicalpathological parameters were analysed. Results： The COX- 2 expression was correlated with TNM stage, neural invasion, differentiation and chemosensitivity to 5 - FU. Conclusion：The COX -2 expression level is associated with tumor metastasis and stage, and the overexpression of COX - 2 in clolorectal cancer were associated with the chemosensitivity to 5 - FU.

关 键 词：环氧化酶-2 结直肠癌 免疫组化 三维微组织块培养法 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]