肝脏原发性癌肉瘤临床病理分析及文献复习  

Carcinosarcoma of the liver:a case report and review of literature

作　　者：高福平[1] 魏谨[1] 马平[1] 孙琼[1] 夏莉花[1] 秦东梅[1] 薛松[1] 李文洁[1] 

机构地区：[1]高淳县人民医院病理科,江苏南京211300

出　　处：《现代肿瘤医学》2014年第4期881-882,共2页Journal of Modern Oncology

基　　金：南京市卫生青年人才培养工程(编号:QRX11344)

摘　　要：目的:探讨肝脏原发性癌肉瘤(primary hepatic carcinosarcoma,PHC)的临床病理特点、免疫表型及鉴别诊断。方法:对1例发生于肝脏的PHC进行组织学观察、免疫组化检查。结果:镜下肿瘤大部分区域由短梭形细胞、多核巨细胞、泡沫状细胞组成,呈旋涡状排列。小部分为异型的腺管状结构。两种区域可见相互移行。免疫组化标记显示肉瘤样区瘤细胞CD68、SMA、S-100呈阳性表达。不表达CK20、EMA、CA19-9、AFP、CKpan。结论:肝脏原发性癌肉瘤是一罕见的高度恶性肿瘤,结合临床病理学特征及免疫组化检查,可做出正确诊断。Objective：To study the clinicopatholocal and immunohistochemical features of primary hepatic carcino- sarcoma（PHC）. Methods：One case of PHC was evaluated by lightmicroscopy and immunohistochemistry. Results： An primary hepatic carcinosarcoma mass was presented in a 66 years old female. She was diagnosed as primary liver cancer before operation. Pathological examination revealed that the tumor was composed of epithelium and mesen- chyme and diagnosed as primary hepatic carcinosarcoma. The tumor cells were showed strong immunostaining with CD68, SMA, S - 100. Other makers including CK20, EMA, CA19 -9 ,AFP and CKpan were all negative, Conclusion： PHC is a high grade malignant liver neoplasm. Careful analysis of the clinicopathological features and immunohisto- chemisitry will be helpful to reach an accurate diagnosis.

关 键 词：肝脏肿瘤 癌肉瘤 病理诊断 鉴别诊断 

分 类 号：R735.7[医药卫生—肿瘤]