^(18)F-FDGPET/CT显像对多发性骨髓瘤诊断效能的回顾性研究  

The diagnostic accuracy of ^(18)F-FDG PET/CT imaging in multiple myeloma-a retrospective study

作　　者：郝珊瑚[1] 张国旭[1] 王志国[1] 张海波[2] 

机构地区：[1]沈阳军区总医院核医学科,辽宁沈阳110840 [2]沈阳军区总医院放射治疗科,辽宁沈阳110840

出　　处：《现代肿瘤医学》2014年第4期903-906,共4页Journal of Modern Oncology

摘　　要：目的:回顾性分析评价18F-FDG PET/CT显像对多发性骨髓瘤的诊断效能。方法:选择本院2011年3月-2013年6月临床可疑多发性骨髓瘤患者39例,其中男性22例,女性17例,年龄44-78岁,平均年龄(51.3±0.5)岁。均行PET/CT检查及临床骨穿或病理活检证实,分别统计其真假阳性例数及真假阴性例数,并计算灵敏度、特异性及准确性指标,评价诊断效能。结果:39例患者中真阳性18例,假阳性2例,真阴性16例,假阴性3例。PET/CT诊断灵敏度为85.7%(18/21),特异性为88.9%(16/18),准确性为87.2%(34/39),阳性预测值为90%(18/20),阴性预测值为84.2%(16/19)。结论:18F-FDG PET/CT可用于多发性骨髓瘤的诊断,结合患者临床表现及生化检查可提高诊断符合率。Objective： To evaluate the diagnostic accuracy of 18 F- FDG PET/CT imaging in multiple myeloma. Methods：All 39 patients with clinically suspected, MM were studied, male： female = 22： 17. Age was 44 -78 years old. All patients underwent 18F -FDG PET/CT imaging and medullary needle biopsy or operation and pathology. True or false positive and true or false negative were recorded and evaluated the diagnostic accuracy. Results：18 of 39 were resulted as MM in 18F -FDG PET/CT imaging, 16 of 18 were reviewed by medullary needle biopsy or operation and pathology,16 of 39 were not resulted as MM in 18F -FDG PET/CT imaging, 13 of 16 were reviewed by medullary needle biopsy or operation and pathology. The sensitivity, specificity, accuracy of diagnosis, positive or negative predictive of MM by 18F - FDG PET/CT imaging were 85.7% （ 18/21 ）, 88.9% （ 16/18 ）, 87.2% （34/39） ,90% （18/20） ,84.2% （16/19） respectivily. Conclusion： 18F - FDG PET/CT imaging has high ability of detecting MM. It will improve the diagnostic accuracy if we consider with clinical test.

关 键 词：多发性骨髓瘤 18氟一脱氧葡萄糖 PET CT 

分 类 号：R733.3[医药卫生—肿瘤]