肝癌发生侵袭与转移分子机制的研究进展  

Research progress of the mechanism on invasion and metastasis of hepatocellular carcainoma

作　　者：郭燕[1] 刘文超[1] 

机构地区：[1]第四军医大学西京医院肿瘤科,陕西西安710032

出　　处：《现代肿瘤医学》2014年第4期932-936,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30973437)

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)在我国为常见的恶性肿瘤。侵袭与转移是肝癌重要的生物学特征,转移和复发是引起肝癌患者死亡的主要因素。肝癌一旦发生转移则明显影响预后。因此,控制肝癌细胞侵袭和转移对于降低肝癌死亡率具有重要意义。本文就近年有关肝癌在侵袭与转移过程中涉及到的生化标志物等研究进展作一综述。Hepatocellular carcinoma（HCC） is one of the most frequent malignancies in our country. Invasion and metastasis are the most important biologic characteristics for HCC. Moreover, metastasis and recurrence is the leading cause of mortality in HCC patients. Once it has progressed to the metastatic stage that is extremely difficuh to treat and does not respond to non - operative treatment. Therefore, the inhibition of invasion and metastasis is the key for the successful treatment of HCC. We will summary the research progress of the mechanism on invasion and metastasis of HCC in this article.

关 键 词：肝癌 侵袭与转移 分子机制 

分 类 号：R735.7[医药卫生—肿瘤]