抑癌基因NDRG2的研究进展  

The latest research progress of tumor suppressor gene NDRG2

作　　者：邓友君 赵勇[2] 麻成方[3] 魏春勇[3] 洪琼川[3] 

机构地区：[1]遵义医学院珠海校区,广东珠海519041 [2]深圳市龙岗中心医院病理科,广东深圳518116 [3]深圳市龙岗中心医院心胸外科,广东深圳518116

出　　处：《现代肿瘤医学》2014年第4期962-965,共4页Journal of Modern Oncology

基　　金：深圳市龙岗区科技发展资金资助项目(编号:YS2012 156)

摘　　要：NDRG2属于NDRG家族(N-myc down-stream regulated gene family),是一种与细胞增殖和分化相关的抑癌基因,分布广泛且生物学功能复杂,在全身多种组织器官均有表达。参与组织胚胎发育、细胞分化并且与血液免疫系统关系密切。在缺血再灌注损伤中对组织起保护作用。与肿瘤的发生、发展和转归密切相关。本文就NDRG2最近研究进展作一综述。NDRG2 belongs to the NDRG family （N -myc down -stream regulated gene family）, is a kind of cell proliferation and differentiation related genes, which widely distributed and has complex biological functions. It is ex- pressed in various organs and tissues, involved in embryonic development, cell differentiation, closely related with the blood immune system, playing the role of protective effects on tissue in ischemia reperfusion injury. Recently, it is found that NDRG2 is closely related to tumorigenesis, development, tumor metastasis and prognosis. This review will discuss the progress research on NDRG2.

关 键 词：抑癌基因 NDRG2 肿瘤标志物 缺血再灌注损伤 CD24 MMP-2 MMP-9 

分 类 号：R730[医药卫生—肿瘤]