Her-2/neu表达对无淋巴结转移早期胃癌患者预后的影响  

Prognostic significance of Her-2/neu expression in patients with early gastric cancer without lymph node metastasis

作　　者：陆礼[1] 刘春娜[1] 付蔚华[1] 刘彤[1] 李卫东[1] 

机构地区：[1]天津医科大学总医院普通外科,天津300052

出　　处：《中国普通外科杂志》2014年第4期425-429,共5页China Journal of General Surgery

摘　　要：目的:探讨Her-2/neu表达及临床病理特征对无淋巴结转移的早期胃癌患者预后的影响。方法:收集70例有完整随访记录和病理组织蜡块保存完整的无淋巴结转移的早期胃癌根治手术切除患者资料,采用免疫组化法检测病理组织切片Her-2/neu表达情况,分析Her-2/neu表达及临床病理因素与患者预后的关系。结果:全组Her-2/neu阳性表达率为25.0%,Her-2/neu表达与患者的性别、年龄、肿瘤大小、分化类型及浸润深度均无明显关系(均P>0.05)。全组5年生存率为87.8%。单因素分析显示,患者性别、年龄、肿瘤大小、肿瘤浸润深度及分化程度对患者生存状况无明显影响(均P>0.05)。Her-2/neu表达阳性患者的5年生存率72.0%,阴性患者为93.0%,差异有统计学意义(P<0.05)。多因素回归分析显示,Her-2/neu的表达为影响预后的危险因素(OR=5.036,P=0.035)。结论:Her-2/neu的表达是影响无淋巴结转移早期胃癌患者预后的危险因素,并对早期胃癌的临床治疗有一定指导意义。Objective： To investigate prognostic significance of HER2/neu expression and different clinicopathological parameters in patients with early gastric cancer （EGC） without lymph node metastasis （pN0）. Methods： Data of 70 patients with NO EGC undergoing radical gastrectomy and complete follow-up, and whose histopathological paraffin blocks were available were collected. The histopathological sections were examined for Her-2/neu expression by immunohistochemical sataining, and the relations of Her-2/neu status and other clinicopathological factors with the outcomes of the patients were analyzed. Results： Her-2/neu positive expression rate was 25.0% of all tissue sections. There was no significantassociation between Her-2/neu expression and age, gender, or tumor size, differentiation and depth of invasion （all P〉0.05）. The overall 5-year survival rate was 87.8% for the entire group of patients. Univariate analysis showed that gender, age, tumor size, depth of invasion, and degree of differentiation had no significant influence on survival of the patients （all P〉0.05）. qhe 5-year survival rate in patients with Her-2/neu positive expression was 72%, while in those with negative expression was 93%, and the difference was statistically significant （P〈0.05）. Multivariate regression analysis showed that Her-2/neu expression was a risk factor for prognosis （0R=5.036, P=0.035）.＇,onclusion： Her-2/neu expression is a risk factor for prognosis ofpNoEGC patients, and has potential value forguiding clinical treatment of EGC.

关 键 词：胃肿瘤 病理学 基因 ERBB-2 预后 

分 类 号：R737.9[医药卫生—肿瘤]