结直肠癌蛋白质标志物研究进展  

Protein markers in colorectal cancer:recent advances

作　　者：崔琳[1] 李立奇[1] 

机构地区：[1]中国人民解放军第三军医大学新桥医院普通外科,重庆400037

出　　处：《中国普通外科杂志》2014年第4期512-516,共5页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81302134)

摘　　要：结直肠癌是世界范围内发病率和致死率最高的恶性肿瘤之一。可靠的肿瘤标志物对指导结直肠癌的诊断、监测治疗效果及预测患者的预后有重要意义。除了临床应用最早也是最广泛的标志物癌胚抗原(CEA)外,近年来,结直肠癌相关标志物研究方面取得了快速进展。笔者主要从血浆、组织及粪便蛋白质标志物3个方面,介绍近年来结直肠癌相关蛋白质标志物的研究进展。Colorectal cancer （CRC） is one of the malignant tumors with the highest incidence and mortality worldwide. Reliable tumor markers of CRC are of prime importance in diagnosis, monitoring treatment and estimating prognosis. In addition to carcinoembryonic antigen （CEA）, the first and most widely used tumor marker, the research in CRC-associated markers had made rapid progress in recent years. In this paper, the authors present the recent progress in CRC-associated protein markers that are mainly derived from serum, tissue and stool.

关 键 词：结直肠肿瘤 诊断 肿瘤标记 生物学 综述文献 

分 类 号：R735.3[医药卫生—肿瘤]