Synthesis of α-Hydroxy-ω-Aminotelechelic Polypeptide from α-Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides  

作　　者：Hui Peng Wan-li Chen Jie Kong Zhi-quan Shen 凌君 

机构地区：[1]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University [2]Center of Analysis & Measurement, Zhejiang University of Technology [3]Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University

出　　处：《Chinese Journal of Polymer Science》2014年第6期743-750,共8页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21174122);Special Funds for Major Basic Research Projects(No.G2011CB606001);Zhejiang Provincial Natural Science Foundation of China(No.Y4110115)

摘　　要：It is reported that alkali-metal borohydrides （MBH4, M = Li, Na and K） are efficient catalysts for ring opening polymerization （ROP） of α-amino acid N-carboxyanhydrides （NCAs）. Polypeptides are prepared in quantitative yields with relatively narrow molecular weight distributions （MWDs = 1.1-1.5） which depend on the reaction temperature. End groups of the produced polypeptide are studied in detail by MALDI-ToF MS, IH-NMR, 13C-NMR, IH-1H COSY and IH-13C HMQC analyses. The results indicate that α-hydroxy-ω-aminotelechelic polypeptides are formed which are suitable for post- polymerization functionalization.It is reported that alkali-metal borohydrides （MBH4, M = Li, Na and K） are efficient catalysts for ring opening polymerization （ROP） of α-amino acid N-carboxyanhydrides （NCAs）. Polypeptides are prepared in quantitative yields with relatively narrow molecular weight distributions （MWDs = 1.1-1.5） which depend on the reaction temperature. End groups of the produced polypeptide are studied in detail by MALDI-ToF MS, IH-NMR, 13C-NMR, IH-1H COSY and IH-13C HMQC analyses. The results indicate that α-hydroxy-ω-aminotelechelic polypeptides are formed which are suitable for post- polymerization functionalization.

关 键 词：POLYPEPTIDE Alkali-metal borohydride α -Amino acid N-carboxyanhydride End group functionalization. 

分 类 号：O631[理学—高分子化学]