多指标综合评分法考察健胃消食片的流化制粒工艺  

Evaluation of fluidized granulation technology of Jianwei Xiaoshi Tablet by multicriteria synthesizing grading method

作　　者：岳国超[1] 陈丽华[1] 刘红宁[1] 黄成 陈小荣 罗晓健[1] 

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [2]江中药业股份有限公司,江西南昌330004

出　　处：《中草药》2014年第7期949-954,共6页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局中药药剂学重点学科(国中医药发[2009]30号)

摘　　要：目的探索多指标评分法用于流化制粒工艺条件优化的可行性，为流化制粒在类似黏性大、制粒困难的物料中的推广应用提供参考。方法运用正交试验设计，测定不同工艺参数下颗粒的物性指标和压片后的片剂质量指标，采用多指标综合评分法评价颗粒和片剂的成型性，优选出最佳的工艺参数。结果优选的最佳流化制粒的处方为进风温度为55℃，进气压力为8kPa，雾化压力为45kPa，进液体积流量为1．0～2．5mL／min。结论多指标综合评分法优化健胃消食片流化制粒工艺稳定、可行，为提高生产效率，改善产品质量提供了理论依据。Objective To explore the feasibility ofmulticriteria synthesizing grading method using in the optimization of the fluidized granulation technology for Jianwei Xiaoshi Tablet （JXT）, and to provide a reference for fluidized granulation technology to spread and apply in the pelletization of materials with strong stickiness. Methods Using orthogonal design, the property parameters of granule and tablet were measured, and the best process parameters were optimized. Results The optimal process parameters were as follows： The inlet air temperature was 55℃, the inlet pressure was 8 kPa, the spray pressure was 30 kPa, and the flow rate of the liquid was 1.0-- 2.5 mL/min. Conclusion The multicriteria synthesizing grading method used in optimizing the fluidized granulation technology of JXT is stable and feasible, and provides theory evidence for improving the productivity and product quality.

关 键 词：流化制粒 健胃消食片 多指标综合评分法 正交试验设计 工艺优化 

分 类 号：R283.6[医药卫生—中药学]