低频强声对大鼠胃肠道传输功能影响的实验研究  

Effect of strong low-frequency sound on the gastrointestinal transmission function of rats

作　　者：刘云涛[1] 屈昌民[2] 吴玮[3] 李连勇[1] 王刚[3] 李斌[4] 梁淑文[1] 

机构地区：[1]解放军第401医院崂山分院耳鼻咽喉头颈外科,青岛266102 [2]解放军第306医院消化内科,青岛266102 [3]解放军第306医院耳鼻咽喉头颈外科,青岛266102 [4]解放军第306医院医务部,青岛266102

出　　处：《中国急救复苏与灾害医学杂志》2014年第4期328-330,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的探讨低频强声对大鼠胃肠道传输功能及形态学的影响。方法随机将大鼠暴露于频率103Hz或300Hz的声场中，暴露时间分别为5min或10min。根据暴露的频率、作用时间，分为4个实验组和对照组。依据暴露后观察时间，每组内再分为即刻、3d和7d三个小组。对低频强声暴露后应用炭粉混悬液法测量胃肠道食物传输功能，并对小肠进行组织病理学观察。结果低频强声暴露后胃肠道食物传输功能明显下降，暴露后不同时间点胃肠道食物传输功能存在差异，P=0．001。所有强声暴露的大鼠中，共有2例出现小肠出血，发生率约为3．7％。结论低频强声可引起大鼠胃肠道传输功能及形态改变。Objective To evaluate the effect of strong low-frequency sound on the gastrointestinal transmission function of rats. Methods The rats were exposed to a closed sound field and acoustically stimulated by using the strong low-frequency sound of 103Hz or 300Hz. The exposure time was set on 5-minute and 10-minute, respectively. The toner advancing distance from the pyloric sphincter to the small intestine was observed immediately, 3 days, and 7 days after the exposure. Results The difference of gastrointestinal transmission function was found among the groups. And the intestinal impairment was found with light microscope. Conclusion Low-frequency sound may affect gastrointestinal transmission function and cost intestine injury.

关 键 词：低频强声 大鼠 胃肠传输功能 形态学 

分 类 号：R573[医药卫生—消化系统]