抗菌墨鱼骨转化羟基磷灰石的制备及其抗菌性能研究  

Preparation and antibacterial property of antibacterial cuttlebone-transformed hydroxyapatite

作　　者：刘明[1] 王小红[1] 刘钟馨[1] 曹阳[1] 王江[1] 

机构地区：[1]海南大学材料与化工学院,海南特有资源与优势化工材料教育部重点实验室,海口570228

出　　处：《化工新型材料》2014年第4期207-209,211,共4页New Chemical Materials

基　　金：海南省重点科技计划(ZDXM20100061;ZDXM20120066);海南省自然科学基金(511106)

摘　　要：采用水热反应和离子交换法,制备了锌掺杂墨鱼骨转化羟基磷灰石(Zn-CBHA)和钛掺杂墨鱼骨转化羟基磷灰石(Ti-CBHA),以及钛与锌共掺杂墨鱼骨转化羟基磷灰石(TiZn-CBHA)。利用EDS、XRD、和FT-IR分别分析了掺杂抗菌墨鱼骨转化羟基磷灰石的组成、晶型和结晶度、结构;通过抑菌环和抗菌率实验,研究了抗菌墨鱼骨转化羟基磷灰石对大肠杆菌、金黄色葡萄球菌的抗菌性能。结果表明:采用水热反应和离子交换法可以制得掺杂墨鱼骨转化羟基磷灰石,Zn-CBHA、Ti-CBHA和TiZn-CBHA对大肠杆菌、金黄色葡萄球菌都具有良好的抗菌性能,锌离子溶出抗菌和钛离子光催化抗菌的协同作用使TiZn-CBHA的抗菌性能增强。Zinc-doped cuttlebone-transformed hydroxyapatite （Zn-CBHA）, titanium-doped cuttlebone-transformed hydroxyapatite（Ti-CBHA）and zinc and titanium co-doped cuttlebone-transformed hydroxyapatite（TiZn-CBHA）were pre- pared by hydrothermal reaction and ion exchange method. The composition, crystal shape and crystallinity, structure of the samples were characterized using EDS, XRD and FTIR. Moreover, the bacterial inhibition zone and antibacterial ratio were tested to investigate the antibacterial properties of antibacterial cuttlebone-transformed hydroxyapatite to Escherichia coli and Staphylococcus aureus. The results indicated that, antibacterial cuttlebone-transformed hydroxyapatite can were pre- pared by hydrothermal reaction and ion exchange method, Zn-CBHA, Ti-CBHA and TiZn-CBHA had good antibacterial properties to Escheriehia coli and Staphylococcus aureus, the synergistic effect of the titanium photocatalytic decomposition antibacterial and zinc ion dissolved out antibacterial, which enhanced the antibacterial property of TiZn-CBHA.

关 键 词：墨鱼骨转化羟基磷灰石 锌掺杂 钛掺杂 共掺杂 抗菌性能 

分 类 号：R318.08[医药卫生—生物医学工程]