牙周炎伴高血压患者牙周临床指标和血清抗心磷脂抗体水平的分析  

Clinical significance of serum levels of anticardiolipin antibody in patients with essential hypertension and periodontitis

作　　者：王雷[1] 赵斌[1] 李红艳[1] 丁子清[1] 

机构地区：[1]吉林大学口腔医院牙周病科,吉林长春130021

出　　处：《牙体牙髓牙周病学杂志》2014年第4期213-215,230,共4页Chinese Journal of Conservative Dentistry

基　　金：吉林大学交叉学科基本科研业务经费资助课题(450060445270);吉林省长春市社会发展科技计划项目资助课题(12SF82)

摘　　要：目的:探讨中、重度慢性牙周炎与原发性高血压之间的关系。方法:纳入慢性牙周炎伴原发性高血压的患者32例,单纯中、重度慢性牙周炎患者38例,健康对照者34例;记录各受试者的菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL)、出血指数(BI)等牙周临床指标后,抽取空腹静脉血并分离血清,采用定量夹心ELISA法检测血清中抗心磷脂抗体IgG(ACA-IgG)、IgM(ACA-IgM)的含量。结果:3组患者中PD、AL、BI各项牙周临床指标以及血清ACA-IgG水平均以慢性牙周炎并发高血压组最高,单纯慢性牙周炎组次之,健康对照组最低,3组间两两相比P<0.05;而血清ACA-IgM水平3组间均无显著性差异(P>0.05);ACA-IgG水平与PLI、PD、AL、BI均呈显著正相关,r值分别为0.419、0.339、0.661、0.472(P<0.05)。结论:高血压可以加重牙周炎患者的牙周破坏程度,而慢性牙周炎可导致高血压患者血清ACA-IgG升高。AIM： To explore the relationship of chronic periodontitis with hypertension. METHODS： Anticardiolipin antibody-IgG（ACA-IgG） and IgM （ACA-IgM） in serum of 32 patients with chronic periodontitis and essential hypertension （CPEH group）, 38 with chronic periodontitis （CP group） and 34 healthy subjects（ control group） were measured by ELISA. Plaque index （ PLI）, probing depth （ PD）, attachment loss （AL） and bleeding index （BI） were recorded. RESULTS： PD, AL and BI in CPEH group were significantly higher than those in CP and control groups （P 〈0.05）. The ACA-IgG level in CPEH group was significantly higher than that in CP and control groups （P 〈 0.05 ）. However, no significant difference was found in ACA-IgM level among the 3 groups （ P 〉 0.05 ）. ACA- IgG level was positively correlated with PLI, PD, AL and BI （ P 〈 0.05 ）. CONCLUSION ： Periodontitis may in- crease the level of serum ACA-IgG in patients with hypertension, and hypertension might increase the severity of peri- odontitis .

关 键 词：牙周炎 原发性高血压 抗心磷脂抗体 

分 类 号：R781.4[医药卫生—口腔医学]