乳腺浸润性导管癌组织FGFR1与AIB1表达及其相关性研究  

Expression and correlation of FGFR1 and AIB1 in invasive ductal carcinoma of breast

作　　者：任冬飞 李庆霞[1] 王泽阳[1] 邢雅军[1] 颜聪亚[1] 张丽霞[1] 李娜[1] 任菊娜[1] 

机构地区：[1]河北省人民医院肿瘤一科,河北石家庄050051

出　　处：《中华肿瘤防治杂志》2014年第8期594-598,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：河北省科技支撑计划(11276103D-70)

摘　　要：目的：探讨乳腺浸润性导管癌（invasive ductal carcinoma，IDc）中成纤维细胞生长因子受体1（fibroblast growth factor receptor1，FGFRl）和乳腺癌扩增性抗原1（amplified in breast cancer 1，AIBl）的表达，分析两者与乳腺IDC临床特征的关系以及两者的相关性。方法：采用免疫组织化学SP法检测2006—01-01—2011-06-30河北省人民医院100例经病理科医师确诊、临床病例资料完整的乳腺IDC组织石蜡标本中FGFRl及AIBl的表达情况，分析两者与临床病理特征的关系及两者的相关性。统计所有数据均采用SPSS17．0统计软件进行分析，采用Y。检验或Fisher确切概率法对同一指标的不同临床病理特征进行比较，应用多因素Logistic回归分析FGFRl及AIBl阳性表达有关的因素，采用Spearman等级相关分析乳腺IDC中FGFRl和AIBl表达的相互关系。结果：FGFRl在乳腺IDC中的阳性表达率为31．oo％，其表达与腋窝淋巴结转移（42．86％珊22．41％）、病理组织学分级（Ⅰ级0，Ⅱ级26．80％，Ⅲ级51．60％）和临床分期（Ⅰ期11．10％，Ⅱ期29．40％，Ⅲ期65．00％）有关，差异均有统计学意义，X^2值分别为4．760、12．463和15．671，P值分别为0．029、0．002和〈0．001；AIBl在乳腺IDC中的阳性表达率为75．00％，与腋窝淋巴结转移与否（83．33％79S68．97％）有关，差异有统计学意义（X^2=4．433，P-0．035），其表达随着病理组织学分级（Ⅰ级38．46％，Ⅱ级75．0。％，Ⅲ级90．32％）和临床分期（Ⅰ期44．44％，Ⅱ期84．31％，Ⅲ～Ⅳ期95．OO％）的增高而逐渐增高，差异均有统计学意义（X^2=13．138，P-0．001；x。=20．336，P〈0．001）；多因素Logistic回归分析显示，组织学分级是影响FGFRl及AIBl阳性表达的最主要因素（wald X^2=13．448，P=0．003；wald X^2=7．958，P一0．001）。FGFRl与AIBl表达在乳腺IDC中呈正相关，r-0．237，P-0．017。结论：FGFROBJECTIVE： To investigate the correlation between the protein expressions of fibroblast growth factor receptorl（FGFR1） and amplified in breast cancer 1 （AIB1） in invasive ductal carcinoma （IDC） of breast and the associa- tions with clinical features. METHODS： S-P Immunohistochemical techniques were adopted to detect the expression of FGFR1 and AIB1 in 100 cases of IDC who were collected from 2006-01-01 to 2011-06-30 in Hebei General Hospital, and had been confirmed by histopathology, with the complete clinical data. SPSS 17.0 statistical software was used for statis- tical analysis. X2 test or Fisher exact Test was used to compare different clinical pathological features of the same parame- ter. Logistic regression analysis was applied for the analysis of positive expression-related factors of FGFR1 and AIB1. Spearman rank correlation was used to analyse the interrelation of FGFR1 and AIB1 in IDC. RESULTS： The positive ex- pression rate of FGFR1 in IDC tissues was 31.00%. The expression of FGFR1 was positively related to the lymph node metastasis（42.86% vs 22.41%）, histological grade（ Ⅰ grade 0, Ⅱ grade 26.80%, Ⅲ grade 51.60%）, clinical stage（Ⅰ staging 11.10 %, Ⅱ staging 29.40 %, Ⅲ-- IV staging 65.00 % ）, with statistical significance （X^2 = 4. 760, P = 0. 029 ; Xz = 12. 463, P= 0. 002; X2= 15. 671, P〈0. 001, respectively）. The positive expression rate of AIB1 in IDC tissues was 75.00%. The positive expression rate of AIB1 in lymph node positive group was significantly higher than that in lymph node negetive group （83.33 % vs 68.970, X^2 = 4. 433, P = 0. 035）, and increased along with the histologic grading （ Ⅰ grade 38.46 %, Ⅱ grade 75.00 %, Ⅲ grade 90.32 % ） and clinical stage（ Ⅰ staging 44.44 %, Ⅱ staging 84.31%, Ⅲ -- Ⅳ stag- ing 95.00%）, the positive expression rate of FGFR1 increased gradually, and the difference was statistically significant （X^2 = 13. 138, P= 0. 001 ; z = 20. 336, P〈0. 001, respectively）. Logistic regression an

关 键 词：乳腺肿瘤 浸润性导管癌 FGFR1 AIB1 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]