异种移植构建小鼠人急性白血病模型的研究进展  

Research Progress on Human Acute Leukemia Xenograft Mouse Models——Review

作　　者：郭嫣婷 李娟[2] 欧阳建[2] 

机构地区：[1]东南大学医学院,江苏南京210009 [2]南京市鼓楼医院血液科,江苏南京210008

出　　处：《中国实验血液学杂志》2014年第2期555-559,共5页Journal of Experimental Hematology

基　　金：国家自然基金(31371399)

摘　　要：构建小鼠人急性白血病模型的方法包括人白血病细胞异种移植、逆转录病毒转导/移植、小鼠转基因、化学诱变、插入诱变等。通过异种移植构建小鼠人急性白血病模型是当前研究急性白血病的重要手段之一。本文就免疫缺陷鼠、预处理及细胞因子、细胞接种、模型评估及模型应用方面,介绍异种移植构建小鼠人急性白血病模型的最新进展。The methods for modeling human acute leukemia in mice include xenotransplantation of human leukemia cells, retroviral transduction/transplantation, transgenesis, chemical mutagenesis and insertional mutagenesis. Establi- shing human acute leukemia mouse models through xenograft is an important way to study acute leukemia. This review focuses on the newest progress of studies on human acute leukemia xenograft mouse models in the regards of the immunodeficiency mouse, preconditioning, cytokines, cell transplantion, the evaluation and application of model.

关 键 词：免疫缺陷鼠 异种移植 急性白血病 小鼠模型 

分 类 号：R733.71[医药卫生—肿瘤] R457.7[医药卫生—临床医学]