雷公藤甲素治疗胰腺癌分子机制的生物信息学分析  

Bioinformatics analysis on molecular mechanism of triptolide in treatment of pancreatic cancer

作　　者：车玉梅[1] 何小鹃[2] 李立[2] 徐洁[1] 王敏智[1] 吕爱平[2] 马超英[1] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国中医基础医学杂志》2014年第4期530-532,536,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家"重大新药创制"科技重大专项项目(2009ZX09502-019);国家自然科学基金资助项目(30902000);中国中医科学院课题(Z0252;Z0218)

摘　　要：目的:通过生物信息学方法探讨雷公藤甲素(TP)治疗胰腺癌分子机制。方法:在PubChem数据库中查找TP活性靶蛋白,在Gene数据库中查找胰腺癌相关基因,运用Ingenuity Pathway Analysis(IPA)软件,构建二者分子网络和生物学通路并解析。结果:二者涉及的生物学通路中有5个共有生物学通路,2条为癌症相关通路,TP可作用癌症相关通路的溶血磷脂酸受体(EDG)、JAK等。结论:TP可通过干预胰腺癌相关的凋亡通路和癌症信号通路上多个位点发挥治疗胰腺癌的作用。Objective： To study the molecular mechanism of triptolide in the treatment of pancreatic cancer by building molecular networks and comparing canonical pathways. Methods ： Target proteins of triptolideand related genes of pancreatic cancer were searched from Pubchem and Gone databases online respectively. Molecular networks and canonical pathways comparison analyses were performed by IPA. Results： The molecular networks of triptolideand pancreatic cancer were complex and muhifunctional. There were 5 common pathways in tfiptolide related bionetworks and pancreatic cancer related networks, and 2 of them were cancer related pathways. Triptolidc could regulate endothelial differentiation, G-protein- coupled （EDG） and Janus-activated kinasc （JAK） in these pathways. Conclusions： Triptolidecould treat pancreatic canccrby rcgulatingmany effective nodes of cancer related pathways.

关 键 词：TP 胰腺癌 IPA PubChem 

分 类 号：R735.9[医药卫生—肿瘤]