健脾扶正汤对晚期胃癌患者生活质量的影响  

Impacts on the Life Quality in the Patients with Advanced Gastric Cancer Treated with Jianpi Fuzheng Decoction

作　　者：向立洋[1] 黄智芬[1] 黎汉忠[1] 陈闯[1] 张作军[1] 陈蔚[1] 袁颖[1] 谭志强[1] 许瑞琪[1] 桂海涛[1] 

机构地区：[1]广西医科大学附属肿瘤医院,广西南宁530021

出　　处：《世界中西医结合杂志》2014年第4期412-415,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：广西壮族自治区中医药管理局自筹基金费科研课题(No.gzzc0974)

摘　　要：目的观察健脾扶正汤对晚期胃癌患者生活质量的影响。方法将60例晚期胃癌患者随机分成治疗组和对照组,每组30例。两组均采用注射用奥沙利铂(草酸铂,L-OHP)、亚叶酸钙(CF)、氟尿嘧啶(5-Fu)方案(FOLFOX4方案)化疗,治疗组加用健脾扶正汤治疗。两组每4周为1个周期,2个周期结束评价疗效。观察两组患者治疗后临床疗效、欧洲癌症研究与治疗组织生活质量核心30问卷调查(EORTCQLQ-C30)、中医证候积分、Karnofsky功能状态评分(KPS评分)及不良反应变化。结果治疗组与对照组中医证候疗效总改善率分别为86.7%、60.0%(P<0.05);两组患者EORTCQLQ-C30(情绪功能与社会功能2项)、中医证候积分、KPS评分变化,差异有统计学意义(P<0.05),治疗后两组患者不良反应状均有不同程度加重,但治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论健脾扶正汤治疗晚期胃癌能增强免疫功能、改善临床症状、减轻不良反应。Objective To observe the impacts on life quality in the patients of advanced gastric cancer treated with Jianpi Fuzheng Decoction. Methods Sixty cases of advanced gastric cancer were ran- domized into a treatment group and a control group,30 cases in each one. The chemotherapy of L- OHP,CF and 5 -Fu program（ FOLFOX4 program）was used in the two groups. In the treatment group, Jianpi Fuzheng Decoction was added. The treatment for 4 weeks made 1 period and the efficacy was evaluated at the end of 2 periods. After treatment, the clinical efficacy, EORTCQLQ - C30, TCM symptom score, KPS score and adverse reactions were observed after treatment in the two groups. Results The total improvement rates were 86.7% and 60.0% in terms of TCM efficacy in the treatment group and the control group respectively（ P 〈 0.05 ）. The differences in EORTCQLQ -C30（ emotional function and social function） ,TCM symptom score and KPS score were significant after treatment between the two groups （ P 〈 0.05 ）. The adverse reactions got worse to different degrees after treatment in the two groups, but the results in the treatment were less than those in the control group, indicating the significant difference （ P 〈 0.05 ）. Conclusion Jianpi Fuzheng Decoction en- hances immune function,relieves clinical symptoms and alleviates adverse reactions in the treatment of ad- vanced gastric cancer.

关 键 词：晚期胃癌 中西医结合疗法 健脾扶正汤 生活质量 

分 类 号：R735.2[医药卫生—肿瘤]