儿童急性白血病患者血清中胰岛素样生长因子1和白血病抑制因子的研究  

The level and clinical significance of insulin-like growth factor 1 and leukemia inhibitory factor in children acute leukemia

作　　者：曾鹏云[1] 岳玲玲[1] 白俊[1] 刘瑛[1] 朱明霞[1] 

机构地区：[1]兰州大学第二医院,兰州730030

出　　处：《中国肿瘤临床与康复》2014年第4期395-397,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨儿童急性白血病患者血清中胰岛素样生长因子1(IGF-1)和白血病抑制因子(LIF)的水平及其临床意义。方法利用酶联免疫吸附法对86例急性白血病患儿进行化疗后血清IGF-1及LIF水平,并与45例正常健康儿童进行比较。结果不同治疗阶段急性白血病患儿血清中IGF-1和LIF水平存在差别,初诊未治组IGF-1水平最低,随治疗时间增长,IGF-1及LIF水平逐渐上升,初诊未治组与短期CR组、长期CR组间差异有统计学意义(P<0.05);正常对照组IGF-1和LIF水平与短期CR组、长期CR组比较,差异无统计学意义(P>0.05)。结论 IGF-1和LIF水平可作为评判儿童急性白血病病情发展和治疗效果的重要指标。Objective To explore the level and clinical significance of insulin-like growth factor 1 （ IGF-1 ） and leukemia inhibitory factor （LIF） in children with acute leukemia （AL）. Methods With the enzyme-linked immuno sorbent assay used, the level of IGF-1 and LIF in the serum of 86 cases with AL after chemotherapy were tested,which had been compared with 45 healthy children. Results The level of IGF-1 and LIF in untreated group were the lowest. The level of IGF-1 and LIF increased gradually with prolonged treatment time. The differences among four groups were statistically significant （ P 〈 O. 05 ）, IGF-1 and LIF level had not statistical significance between short stage CR group, long stage CR group and normal control group（P〉0.05）. Conclusion IGF 1 and LIF level can be used as indicators to estimate the illness and treatment effect in children with AL.

关 键 词：急性白血病 胰岛素样生长因子1 白血病抑制因子 

分 类 号：R733.71[医药卫生—肿瘤]