Nkx2.5基因与先天性心脏病  

Gene Nkx2.5 and congenital heart disease

作　　者：蔡花[1] 付四清[2] 

机构地区：[1]华中科技大学同济医学院第一临床学院,湖北武汉430030 [2]华中科技大学同济医学院医学遗传学系,430030

出　　处：《中国优生与遗传杂志》2014年第4期1-3,共3页Chinese Journal of Birth Health & Heredity

摘　　要：先天性心脏病(CHD)是人类出生缺陷中最常见的畸形,也是婴幼儿非感染性疾病中最主要的死亡原因。大量研究表明Nkx2.5是重要的转录因子,在心脏发育过程中起很重要的作用,该基因的突变将影响心脏发育导致先心病。本文就Nkx2.5基因与先心病的关系与最新进展予以综述。Common birth defect, also is the leading cause of death in non - infectious diseases of infants. Numerous studies show that Nkx2. 5 is important transcription factor that plays an important role during cardiac development, the mutation will affect the devel- opment of the heart lead to congenital heart disease. In the present review, the relationship and the current progress of Nkx2. 5 and congenital heart disease were summarized.

关 键 词：先天性心脏病 Nkx2 5 基因突变 

分 类 号：R541.1[医药卫生—心血管疾病]