单纯性肥胖儿童血浆同型半胱氨酸、D-二聚体水平变化及相关因素分析  

Analysis on changes and related factors of plasma homocysteic acid and D-dimer levels in children with simple obesity

作　　者：杨玲 杨帅 廖道明 胡美荣 胡丽华 廖娟萍 杨韵梅 

机构地区：[1]江西省瑞金市人民医院儿科,342500

出　　处：《中国妇幼保健》2014年第14期2168-2171,共4页Maternal and Child Health Care of China

基　　金：赣州市指导性科技项目〔2012306〕

摘　　要：目的:以赣南地区单纯性肥胖儿童为研究对象,探讨血浆同型半胱氨酸(Hcy)、D-二聚体(D-D)水平变化与血压、体重指数(BMI)、血脂代谢的相关性和临床意义。方法:30例单纯性肥胖患儿及30例健康体检儿童,采用问卷调查及体格测量方法收集入选儿童人口学资料(年龄、血压、BMI、生活习惯、疾病遗传史等),同时取禁食12 h儿童以上的静脉血,检测血浆Hcy、D-D、血浆甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-Ch)、低密度脂蛋白(LDL-Ch)水平。结果:两组不同性别儿童血浆Hcy、D-D浓度比较无统计学差异(P>0.05)。与健康非肥胖儿童相比,单纯性肥胖儿童血压、BMI、Hcy、D-D、TG、TC、LDL-Ch水平明显增高(P<0.05),HDL-Ch浓度明显降低(P<0.01)。肥胖儿童随着肥胖程度的增加,血浆Hcy,TG、TC、LDL-Ch浓度逐渐增加(P<0.05)。肥胖组BMI与血压、TG、TC水平呈正相关,血浆Hcy与血压、BMI、TG、TC水平呈正相关,D-D与HDL-Ch水平呈正相关。结论:赣南地区单纯性肥胖儿童有明显的血压、脂质代谢异常,易发生动脉粥样硬化性疾病。单纯性肥胖儿童血浆Hcy、D-D明显增高,均可作为反映儿童单纯性肥胖症心血管严重事件高风险的较敏感、可靠的指标,具有一定的临床意义。Objective： To explore the clinical significances and correlation between changes of plasma homocysteic acid （Hcy） , D- dimer （D -D） levels and blood pressure, body mass index （BMI）, blood lipid metabolism of children with simple obesity in south of Jiangxi province. Methods： Thirty children with simple obesity and thirty healthy children receiving physical examination in the hospital were selected as study group and control group, respectively; the demographic data （age, blood pressure, BMI, living habits, history of ge- netic diseases） of children in the two groups were collected by questionnaire investigation and physical measurement ; after absolute diet more than 12 hours, the venous blood specimens were abstracted to detect the plasma levels of Hcy, D- D, triglycerides （TG）, total cholesterol （ TC）, high - density lipoprotein cholesterol （ HDL - Ch） and low density lipoprotein cholesterol （ LDL - Ch） . Results ： There was no sta- tistically significant difference in plasma Hcy and D - D concentrations between the two groups （ P 〉 0. 05 ） . Compared with control group, blood pressure, BMI, Hey, D - D, TG, TC and LDL - Ch levels in study group increased significantly （ P 〈 0. 05 ） , HDL - Ch concentra- tion decreased significantly （P 〈 0. 01 ） . The concentrations of plasma Hcy, TG , TC and LDL - Ch increased gradually with the aggrava- tion of obesity in study group （ P 〈 0.05 ） . In study group, BMI was positively correlated with blood pressure, TG and TC, plasma Hcy was positively correlated with blood pressure, BMI, TG and TC. D- D was positively correlated with HDL- Ch level. Conclusion： There are significant abnormalities of blood pressure and fat metabolism in children with simple obesity in south of Jiangxi province, so atherosclerosis occurs easily in these obese children. The concentrations of plasma Hcy and D - D have increase significantly in simple obese children, which can be used as relatively sensitive and reliable indexes to refle

关 键 词：单纯性肥胖 心血管严重事件 同型半胱氨酸 D-二聚体儿童 

分 类 号：R153.2[医药卫生—营养与食品卫生学]