江苏盐城宫颈癌及癌前病变危险因素人群归因危险度研究  

Study on population attributable risk of risk factors of cervical cancer and cervical precancerous lesion in Yancheng city of Jiangsu province

作　　者：王春桃[1] 梁戈玉[2] 许红[1] 付艳云[2] 马书梅[2] 张艳秋[2] 隋静[2] 吴慧玲[1] 

机构地区：[1]盐城卫生职业技术学院护理学院,江苏盐城224001 [2]东南大学公共卫生学院环境医学工程教育部重点实验室

出　　处：《中国妇幼保健》2014年第14期2223-2225,2252,共4页Maternal and Child Health Care of China

基　　金：江苏省六大人才高峰项目〔2013-WSW-053〕;江苏省大学生实践创新训练计划立项项目〔201312682001Y〕;江苏省青蓝工程项目〔2012〕;盐城市医学科技发展计划项目〔YK2013060〕

摘　　要：目的:探讨江苏盐城地区宫颈癌及癌前病变的危险因素,为有效开展预防工作提供科学依据。方法:采取病例-对照研究方法,对115例宫颈癌患者和132例对照者的一般状况、疾病认知情况、月经婚孕史、性行为史、生活方式、生殖道既往患病史、家族史等进行调查,通过单因素及多因素统计分析其危险因素,并计算人群归因危险度(PAR)。结果:被动吸烟量、生殖道既往病史、使用避孕套避孕、性生活后阴道冲洗、5年内是否参加宫颈癌筛查与宫颈癌及癌前病变发生密切相关(P<0.05),其OR值分别为2.213、3.104、0.141、0.219、5.001,调整PAR分别为52.28%、41.85%、79.18%、27.83%、44.52%,综合PAR为93.35%。结论:正确了解宫颈癌及癌前病变发生的危险因素,采取针对性的有效措施,可有效预防女性宫颈癌和癌前病变的发生。Objective： To explore the risk factors of cervical cancer and cervical precancerous lesion in Yancheng city of Jiangsu province, provide scientific basis for effective prevention and intervention of cervical cancer and cervical precancerous lesion. Methods： A case -control study was used to investigate the general conditions, the cognitions for disease, menstruation, marriage and pregnancy histo- ries, sex behavior histories, life styles, reproductive previous medical and family histories among 115 patients with cervical cancer and 132 normal women. The risk factors were analyzed by univariate analysis and multivariate analysis, and population attributable risk （PAR） was calculated. Results： Passive smoking, previous reproductive medical history, condom use for contraception, vaginal douche after sexual life, and joining in cervical cancer screening within 5 years or not were closely related to cervical cancer and precancerous lesion （ P 〈 0.05） , OR values were 2. 213, 3. 104, 0. 141, 0. 219 and 5. 001, respectively, and adjusted PAR were 52. 28% , 41.85% , 79. 18% , 27.83% and 44. 52% , respectively. The synthesized PAR of these risk factors was 93.35%. Conclusion： Correct understanding the risk factors of cervical cancer and cervical precancerous lesion and taking effective measures can effectively prevent cervical cancer and cervical precancerous lesion.

关 键 词：宫颈癌 癌前病变 危险因素人群归因危险度 

分 类 号：R737.33[医药卫生—肿瘤]