18F-FDGPET／CT与血清CEA测定联合应用对结直肠癌术后复发与转移的临床诊断价值  

The Clinical Value of the Combination of18F-FDG PET/CT and Serum CEA on the Diagnosis for Recurrence and Metastasis of Colorectal Cancer Postoperation

作　　者：张旭初[1] 王荣福[1] 张建华[1] 范岩[1] 付占立[1] 张春丽[1] 赵光宇[1] 陈立新[1] 

机构地区：[1]北京大学第一医院,北京100034

出　　处：《肿瘤学杂志》2014年第4期300-304,共5页Journal of Chinese Oncology

基　　金：国家重大科学仪器设备开发专项(2011YQ03011409);国家自然科学基金(81071183)

摘　　要：[目的]探讨18F-FDG PET/CT在结直肠癌术后血清CEA升高患者探测复发及转移灶中的应用。[方法]64例结直肠癌术后血清CEA升高患者均进行了18F-FDG PET/CT显像,并与病理及临床随访结果进行比较。[结果]PET/CT诊断阳性56例,1例假阳性;阴性8例,2例假阴性。PET/CT诊断灵敏度为96.5%,特异性为85.7%,阳性预测值为98.2%,阴性预测值为75.0%,准确率为93.8%。[结论]应用18F-FDG PET/CT检查对于结直肠癌术后血清CEA升高患者复发及转移灶的探测具有较高的灵敏度及特异性,血清CEA升高可以作为18F-FDG PET/CT检查前初筛的良好指标。[Purpose] To investigate the clinical value of 18F-FDG PET/CT for detecting the re- curence and metastasis of the elevated serum eareinoembryonic antigen （CEA） in patients with colorectal cancer postoperation. [Methods ] 18F-FDG PET/CT were performed in 64 patients with elevated CEA. PET/CT results were compared with the final histopathological and clinical fol- low-up findings. [Results] PET/CT was positive in 56 patients and negative in 8 patients. After correlated with histopathology or radiology and clinical follow-up,PET/CT was false positive in 1 patient,false negative in 2 patients. The sensitivity,specificity,positive predictive value,nega- tive predictive value and accuracy of 18F-FDG PET/CT were 96.5%,85.7%,98.2%,75.0% and 93.8%,respectively. [Conclusion]18F-FDG PET/CT can significantly improve diagnostic accu- racy in patients with colorectal cancer postoperation. The elevated serum CEA is an effective sig- nal for the patients that should be detective by PET/CT for finding recurrence of colorectal cancer.

关 键 词：结直肠肿瘤 复发 转移 正电子发射断层显像术 X线计算机 癌胚抗原 

分 类 号：R735.3[医药卫生—肿瘤]